Potential of Cyclosporine in the Treatment of Psoriasis: Trends, Scope and Relevance Providing Newer Insights Into Immune Mechanisms

Psoriasis is an immune-mediated disease characterized by abnormal proliferation of keratinocytes. Cyclosporine's effectiveness in treating psoriasis has reshaped the understanding and treatment of the disease. The ability of cyclosporine to inhibit cytokine production by T cells has been a pivotal discovery in the field of psoriasis research.

The role of cyclosporine in elucidating the immune mechanisms underlying psoriasis and its contribution to the emergence of targeted T cell therapies mark a significant turning point in the approach to treating psoriasis. Moreover, the effectiveness of cyclosporine against all forms of psoriasis, its rapid onset of action, and its success in patients experiencing severe psoriatic flare have further solidified its significance in psoriasis treatment.

The use of cyclosporine has not only provided important insights into the immune mechanisms underlying psoriasis but has also paved the way for newer strategies targeting T cells implicated in the disease's pathogenesis. The impact of cyclosporine on cytokine levels in psoriasis has been elucidated through this review.