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Purpose of Review <p>Resistant starch (RS) has been widely investigated as a dietary component with potential metabolic benefits, including improved insulin sensitivity, lipid profile, and inflammatory markers. However, clinical findings remain inconsistent, particularly regarding RS type and dosage. This integrative review aimed to synthesize evidence on the effects of RS consumption in dietary interventions on metabolic and cardiovascular parameters in adults and older adults.</p> Recent Findings <p>RS intake, particularly RS2 and RS3, was associated with significant reductions in postprandial glucose, insulin, and HOMA-IR, as well as improvements in total cholesterol, LDL-C, and triglycerides. Additional findings indicated modest decreases in blood pressure and central adiposity, linked to increased short-chain fatty acid production and higher GLP-1 and PYY levels.</p> Summary <p>Despite promising results, methodological heterogeneity and short intervention durations limit the strength of conclusions. RS shows potential as a functional nutrient for cardiometabolic modulation, particularly for glycemic and lipid control. However, longer, standardized clinical trials are required to confirm efficacy and clarify its physiological mechanisms.</p> Graphical Abstract <p></p>

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Resistant Starch as a Functional Nutrient to Control Cardiometabolic Risk Factors in Humans: An Integrative Review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月30日

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  • Isabela Ribeiro Grangeira Tavares,
  • Eduardo Éric Almeida do Carmo,
  • Thiago da Silveira Alvares

摘要

Purpose of Review

Resistant starch (RS) has been widely investigated as a dietary component with potential metabolic benefits, including improved insulin sensitivity, lipid profile, and inflammatory markers. However, clinical findings remain inconsistent, particularly regarding RS type and dosage. This integrative review aimed to synthesize evidence on the effects of RS consumption in dietary interventions on metabolic and cardiovascular parameters in adults and older adults.

Recent Findings

RS intake, particularly RS2 and RS3, was associated with significant reductions in postprandial glucose, insulin, and HOMA-IR, as well as improvements in total cholesterol, LDL-C, and triglycerides. Additional findings indicated modest decreases in blood pressure and central adiposity, linked to increased short-chain fatty acid production and higher GLP-1 and PYY levels.

Summary

Despite promising results, methodological heterogeneity and short intervention durations limit the strength of conclusions. RS shows potential as a functional nutrient for cardiometabolic modulation, particularly for glycemic and lipid control. However, longer, standardized clinical trials are required to confirm efficacy and clarify its physiological mechanisms.

Graphical Abstract