Scholarlink

Purpose of review <p>This review explores the emerging role of zinc (Zn) as a critical regulator of adipose organ structure and function, highlighting how Zn-related molecular networks contribute to the pathogenesis of obesity and associated metabolic disorders.</p> Recent findings <p>Experimental Zn-deficient models, and genetically-modified Zn-associated proteins, including Zn transporters [i.e., ZnTs (SLC30 family) and Zips (SLC39 family)], zinc-α<sub>2</sub>-glycoprotein (ZAG), metallothioneins (MTs), and zinc finger proteins (ZFPs), demonstrate that Zn is indispensable for maintaining adipose organ integrity. Loss of these proteins disrupts adipogenesis, promotes adipocyte hypertrophy, induces macrophage infiltration and M<sub>1</sub> polarization, and drives pathological visceral fat expansion, resulting in systemic metabolic dysregulation.</p> Summary <p>Zn plays a pivotal role in preserving adipose organ health and systemic metabolic balance. Further investigation is needed to elucidate depot-specific effects of Zn and the coordinated roles of Zn-handling proteins in adipose tissue, which may open new avenues for therapeutic strategies against obesity and metabolic diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Zinc and Adipose Organ Dysfunction: Molecular Insights into Obesity and Metabolic Disorders

  • 期刊论文

  • 发表日期：

    2025年10月24日

查看全文
  • Zahra Bahadoran,
  • Fateme Ghafouri-Taleghani,
  • Marijana Todorčević

摘要

Purpose of review

This review explores the emerging role of zinc (Zn) as a critical regulator of adipose organ structure and function, highlighting how Zn-related molecular networks contribute to the pathogenesis of obesity and associated metabolic disorders.

Recent findings

Experimental Zn-deficient models, and genetically-modified Zn-associated proteins, including Zn transporters [i.e., ZnTs (SLC30 family) and Zips (SLC39 family)], zinc-α2-glycoprotein (ZAG), metallothioneins (MTs), and zinc finger proteins (ZFPs), demonstrate that Zn is indispensable for maintaining adipose organ integrity. Loss of these proteins disrupts adipogenesis, promotes adipocyte hypertrophy, induces macrophage infiltration and M1 polarization, and drives pathological visceral fat expansion, resulting in systemic metabolic dysregulation.

Summary

Zn plays a pivotal role in preserving adipose organ health and systemic metabolic balance. Further investigation is needed to elucidate depot-specific effects of Zn and the coordinated roles of Zn-handling proteins in adipose tissue, which may open new avenues for therapeutic strategies against obesity and metabolic diseases.