Purpose of Review <p>This review explores the impact of <i>Lactiplantibacillus plantarum</i> on diabetes management and discusses the potential mechanism.</p> Recent Findings <p>Recent studies have highlighted that gut dysbiosis has emerged as a key factor in the development of diabetes. In this context, probiotics, specifically <i>Lactiplantibacillus plantarum</i>, offer potential benefits in modulating gut microbiota and improving metabolic health. Several studies have demonstrated the positive impact of <i>L. plantarum</i> on glycemic control, insulin sensitivity, and inflammatory markers in diabetic animal models. The potential mechanisms of action of <i>L. plantarum</i> in diabetes management include inhibiting enzymes involved in glucose metabolism, modulating inflammatory responses, improving insulin sensitivity, restoring gut microbiota, and producing short-chain fatty acids.</p> Summary <p>Summary: The article concludes that <i>L. plantarum</i> is a promising candidate for managing glucose hemostasis, thus offering a potential alternative or adjunct to conventional approaches. However, further clinical studies are necessary to understand the exact mechanism and long-term effects of <i>L. plantarum</i> in humans.</p> Graphical Abstract <p></p>