Purpose of Review <p>This review evaluates current research on grape-based interventions and their impact on cognitive and mental health. It also explores the putative mechanisms by which the grape-derived compounds might modulate cognitive function. The growing prevalence of cognitive decline and mental health disorders necessitates exploring novel dietary approaches. Grapes, rich in polyphenols, have demonstrated potential benefits in preclinical studies. However, translating these findings to humans remains an ongoing endeavor.</p> Recent Findings <p>Recent clinical trials complement existing observational data, suggesting a positive influence of grape consumption on cognition, particularly in areas of memory, learning, and overall cognitive function and emotional well-being. The potential mechanisms involve the antioxidant and anti-inflammatory properties of grapes, which may mitigate neuroinflammation and protect brain cells from free radical damage.</p> Summary <p>Evidence from existing research suggests that grape based interventions may improve cognitive performance through several neuroprotective mechanisms; however, further investigation is needed to understand the protective effects of grape-based interventions on brain function and mental health. Large-scale trials to assess the long-term effects and safety profile of grape interventions are required. Additionally, extensive epidemiological research is needed to confirm the effect of grape interventions on cognitive health and to determine the best beneficial dosage and duration of supplementations to maximise cognitive benefits.</p>