Purpose of Review <p>This manuscript reviews technical principles, clinical applications, and growing evidence around the use of diaphragmatic ultrasound (DU) as a practical, accurate, and reproducible tool for evaluating diaphragm function — with an emphasis on its role in predicting weaning outcomes from mechanical ventilation. This review outlines the standard techniques for performing DU, including assessing diaphragmatic excursion and thickening fraction. Additionally, we synthesize current literature that utilizes DU as a tool for predicting ventilator weaning success.</p> Recent Findings <p>DU has utility as a tool to assess diaphragm function. Multiple studies have used DU as a tool to predict successful ventilator weaning.</p> Summary <p>DU is a versatile, accessible modality that overcomes many limitations of traditional assessments. As evidence continues to expand, adoption of DU will require continued emphasis on training, standardization, and studying clinical integration.</p>