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<p>Ten novel trichothecene sesquiterpenoids including two new <i>seco</i>-trichothecenes, trichotheciumones A (<b>1</b>) and B (<b>2</b>), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (<b>3</b>), and seven new trichothecene sesquiterpenoids, trichothecrotocins T−Z (<b>4</b>−<b>10</b>), together with three new natural products (<b>11</b>−<b>13</b>) and thirteen known compounds (<b>14</b>−<b>26</b>), were isolated from the soil fungus <i>Trichothecium</i> sp. DWS815. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic analyses and quantum chemistry ECD calculations. Given the notable anticancer properties of known trichothecenes, the isolated compounds were evaluated for the cytotoxic activities against three cancer cell lines (HCT116, 4T1, MHCC97H) and one normal cell line (GES-1). Cell cycle analysis revealed new compounds <b>7</b> and <b>8</b> induced G2/M phase arrest in HCT116 cancer cells, which resulted to cell proliferation inhibition activity.</p> Graphical Abstract <p></p>

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Cytotoxic trichothecene derivatives from Trichothecium sp. DWS815

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月3日

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  • Peng-Ju Xu,
  • Ai-Lin Liang,
  • Wen-Yu Lu,
  • Hong-Ping Long,
  • Qing-Hui Xiao,
  • Qi-An Chen,
  • Meng-Lan Hu,
  • Ngoc Nhu Thao Nguyen,
  • Shao Liu,
  • Jing Li,
  • Wen-Xuan Wang

摘要

Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new trichothecene sesquiterpenoid glycoside, trichothecinoside A (3), and seven new trichothecene sesquiterpenoids, trichothecrotocins T−Z (4−10), together with three new natural products (11−13) and thirteen known compounds (14−26), were isolated from the soil fungus Trichothecium sp. DWS815. The structures and absolute configurations of the new compounds were elucidated by extensive spectroscopic analyses and quantum chemistry ECD calculations. Given the notable anticancer properties of known trichothecenes, the isolated compounds were evaluated for the cytotoxic activities against three cancer cell lines (HCT116, 4T1, MHCC97H) and one normal cell line (GES-1). Cell cycle analysis revealed new compounds 7 and 8 induced G2/M phase arrest in HCT116 cancer cells, which resulted to cell proliferation inhibition activity.

Graphical Abstract