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<p><i>Hippophae rhamnoides</i> L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids (<b>1</b>–<b>3</b>), together with sixteen known compounds (<b>4</b>–<b>19</b>). Their structures and absolute configurations were determined using comprehensive spectroscopic analyses and quantum chemical computations of electronic circular dichroism (ECD) spectra and <sup>13</sup>C NMR shifts. Three new sesquiterpenoids (<b>1</b>–<b>3</b>) were tested for their antioxidant, anti-inflammatory, antibacterial, and <i>α</i>-glucosidase inhibitory activities. Unfortunately, none exhibited significant activity under the tested conditions. Among the isolated known compounds, all those displaying <i>α</i>-glucosidase inhibitory and antibacterial activities are pentacyclic triterpenoids. Hippophamide (<b>17</b>) showed significant DPPH and ABTS radical-scavenging activity. These results enriched the chemical profile of <i>H. rhamnoides</i> roots.</p> Graphical Abstract <p></p>

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Three new 14-noreudesmane-type sesquiterpenoids from the roots of Hippophae rhamnoides

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月4日

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  • Fatima Abdurrahman Galadanchi,
  • Polina Lopukhina,
  • Sisi Bai,
  • Guohao Dong,
  • Zhongyu Zhou,
  • Haihui Xie,
  • Xiaoyi Wei

摘要

Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids (1–3), together with sixteen known compounds (4–19). Their structures and absolute configurations were determined using comprehensive spectroscopic analyses and quantum chemical computations of electronic circular dichroism (ECD) spectra and 13C NMR shifts. Three new sesquiterpenoids (1–3) were tested for their antioxidant, anti-inflammatory, antibacterial, and α-glucosidase inhibitory activities. Unfortunately, none exhibited significant activity under the tested conditions. Among the isolated known compounds, all those displaying α-glucosidase inhibitory and antibacterial activities are pentacyclic triterpenoids. Hippophamide (17) showed significant DPPH and ABTS radical-scavenging activity. These results enriched the chemical profile of H. rhamnoides roots.

Graphical Abstract