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<p>Five new <i>α</i>-pyrones, diaporpyrones G-K (<b>1</b>–<b>5</b>) and three new <i>γ</i>-butenolide derivatives, porbutenolides A-C (<b>6</b>–<b>8</b>), along with seven known compounds (<b>9</b>–<b>15</b>), were isolated from the culture extract of the endophytic fungus <i>Diaporthe</i> sp. CCY4. Their structures were elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data. The absolute configurations of <b>7</b> and <b>8</b> were assigned using electronic circular dichroism (ECD) calculations. All compounds were evaluated for inhibitory activity against ubiquitin-specific peptidase 4 (USP4). Compounds <b>2</b>,<b> 5</b>,<b> 9</b>, and <b>13</b> exhibited significant anti-ubiquitination effects at 40&#xa0;μM, with <b>13</b> showing the most potent inhibition (IC<sub>50</sub> = 20.85&#xa0;μM).</p> Graphical Abstract <p></p>

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Eight new α-pyrone and γ-butenolide derivatives from the plant endophytic fungus Diaporthe sp. CCY4

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月3日

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  • Jie-Chun Zeng,
  • Xu-Ping Zhang,
  • Lu Gao,
  • Qian-Qian Yin,
  • Wei-Guang Wang

摘要

Five new α-pyrones, diaporpyrones G-K (1–5) and three new γ-butenolide derivatives, porbutenolides A-C (6–8), along with seven known compounds (9–15), were isolated from the culture extract of the endophytic fungus Diaporthe sp. CCY4. Their structures were elucidated by comprehensive spectroscopic analysis, including 1D/2D NMR and HRESIMS data. The absolute configurations of 7 and 8 were assigned using electronic circular dichroism (ECD) calculations. All compounds were evaluated for inhibitory activity against ubiquitin-specific peptidase 4 (USP4). Compounds 2, 5, 9, and 13 exhibited significant anti-ubiquitination effects at 40 μM, with 13 showing the most potent inhibition (IC50 = 20.85 μM).

Graphical Abstract