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<p>Phytochemical study of the EtOAc extract of <i>Ophiorrhiza brevidentata</i> resulted in the discovery of 10 new monoterpene indole alkaloids (<b>1–10</b>), along with 13 known compounds (<b>11 − 23</b>). Compound <b>1</b> possess an unprecedented skeleton consisting of fused 6/5/6/7/6 polycyclic systems. The structural characterization of these compounds was achieved using Nuclear Magnetic Resonance, Mass Spectrometry and Quantum Chemical Calculations. Compounds <b>3–5</b> and <b>9</b> exhibited strong inhibition on lipopolysaccharide-induced B cell proliferation with IC<sub>50</sub> values ranging from 3.6–9.1&#xa0;µM with excellent selectivity indices (SI &gt; 10).</p> Graphical abstract <p></p>

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Monoterpene indole alkaloids from the aerial parts of Ophiorrhiza brevidentata and their immunological activities

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月11日

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  • Fan Xu,
  • Zheng-Hui Li,
  • Meng-Lin Feng,
  • Jia-Yu Jin,
  • Bao-Bao Shi,
  • Ji-Kai Liu

摘要

Phytochemical study of the EtOAc extract of Ophiorrhiza brevidentata resulted in the discovery of 10 new monoterpene indole alkaloids (1–10), along with 13 known compounds (11 − 23). Compound 1 possess an unprecedented skeleton consisting of fused 6/5/6/7/6 polycyclic systems. The structural characterization of these compounds was achieved using Nuclear Magnetic Resonance, Mass Spectrometry and Quantum Chemical Calculations. Compounds 3–5 and 9 exhibited strong inhibition on lipopolysaccharide-induced B cell proliferation with IC50 values ranging from 3.6–9.1 µM with excellent selectivity indices (SI > 10).

Graphical abstract