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<p>Two new together with 32 known compounds were isolated from the leaves of <i>Lycium barbarum</i>. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds <b>1–34</b> were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds <b>1–</b><b>3</b>, <b>6</b>, <b>8</b>, <b>10</b>, <b>14</b>, <b>17–19</b>, <b>29</b> and <b>31</b> inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20&#xa0;μM. Among them, compound <b>1</b> showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH.</p> Graphical Abstract <p></p>

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Chemical constituents of Lycium barbarum leaves and their anti-rheumatoid arthritis activity in vitro

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月30日

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  • Zi-Jiao Wang,
  • Bang-Yin Tan,
  • Yun Zhao,
  • Chang-Bin Wang,
  • Yun-Li Zhao,
  • Xiao-Dong Luo

摘要

Two new together with 32 known compounds were isolated from the leaves of Lycium barbarum. Their structures were elucidated using 1D and 2D NMR, HRESIMS, and ECD spectroscopic techniques. Compounds 1–34 were evaluated for their anti-rheumatoid arthritis activities in a lipopolysaccharide (LPS)-induced MH7A cells inflammatory model. As a result, compounds 1–3, 6, 8, 10, 14, 17–19, 29 and 31 inhibited the activity of lactate dehydrogenase (LDH) and nitric oxide (NO) at concentrations 20 μM. Among them, compound 1 showed the best effectiveness, with inhibition rates of 46.7% for NO and 32.8% for LDH.

Graphical Abstract