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<p>Two new cytochalasans, xylariaides A (<b>1</b>) and B (<b>2</b>), were isolated and identified from a soil fungus <i>Xylaria</i> sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) <sup>13</sup>C NMR chemical shifts, electronic circular dichroism (ECD), and spin–spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.</p> Graphical Abstract <p></p>

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Xylariaides A and B, novel cytochalasans with a unique 5/6/5/3 ring system from a soil fungus Xylaria sp. Y01

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月7日

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  • Yi-Yun Yuan,
  • Yan Li,
  • Wen-Yu Lu,
  • Ai-Lin Liang,
  • Jing Li,
  • Wen-Xuan Wang

摘要

Two new cytochalasans, xylariaides A (1) and B (2), were isolated and identified from a soil fungus Xylaria sp. Y01. Their structures were unambiguously determined by extensive spectroscopic methods including high resolution electrospray ionization mass spectrometry, ultraviolet radiation, infrared spectroscopy, and 1D/2D NMR, as well as in-depth quantum chemical calculations of gauge-including atomic orbital (GIAO) 13C NMR chemical shifts, electronic circular dichroism (ECD), and spin–spin coupling constants. The unprecedented core structure with a 5/6/5/3 fused tetracyclic ring system further enriches the scaffold types of cytochalasans.

Graphical Abstract