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<p>Phytochemical study of the <i>n</i>-BuOH extract of <i>Ilex asprella</i> resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (<b>1</b>−<b>9</b>) and one oleanane-type glycoside (<b>10</b>), along with seven known compounds (<b>11</b>−<b>17</b>). Compound <b>1</b> is the first reported 19,22-epoxy ursane triterpenoid glycoside, whereas <b>4</b> and <b>5</b> are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group. The structural characterization of these compounds was achieved using spectroscopic and chemical techniques, as well as single-crystal X-ray analysis. Compounds <b>7</b>, <b>12</b>, <b>15</b>, and <b>17</b> exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.</p> Graphical abstract <p></p>

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Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of Ilex asprella

  • 期刊论文

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  • 发表日期：

    2025年3月13日

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  • Yuwei Wu,
  • Baihui Zhang,
  • Wenxian Li,
  • Lihua Peng,
  • Weilin Qiao,
  • Wei Li,
  • De-an Guo

摘要

Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid glycosides, comprising nine ursane-type glycosides (1−9) and one oleanane-type glycoside (10), along with seven known compounds (11−17). Compound 1 is the first reported 19,22-epoxy ursane triterpenoid glycoside, whereas 4 and 5 are rare examples of ursane triterpenoid glycosides containing a 28,19-lactone group. The structural characterization of these compounds was achieved using spectroscopic and chemical techniques, as well as single-crystal X-ray analysis. Compounds 7, 12, 15, and 17 exhibited moderate cytotoxic activities against H1975 and HCC827 cancer cells.

Graphical abstract