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<p>A chemical investigation of <i>Streptomyces</i> sp. GZWMJZ-662, an endophytic actinomycete isolated from <i>Houttuynia cordata</i> Thunb., has yielded eleven bohemamine dimers (<b>1</b>–<b>11</b>). Notably, the newly identified dibohemamines I–O (<b>1</b>–<b>7</b>) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (<b>1</b>) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24 ± 0.20 and 7.36 ± 0.41&#xa0;μM, respectively.</p> Graphical Abstract <p></p>

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Dibohemamines I–O from Streptomyces sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Houttuynia cordata Thunb.

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  • 发表日期：

    2025年1月6日

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  • Dong-Yang Wang,
  • Ming-Xing Li,
  • Yan-Chao Xu,
  • Peng Fu,
  • Wei-Ming Zhu,
  • Li-Ping Wang

摘要

A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb., has yielded eleven bohemamine dimers (1–11). Notably, the newly identified dibohemamines I–O (1–7) have not been previously reported. Their structures were elucidated through detailed spectroscopic analysis, encompassing high-resolution electrospray ionization mass, nuclear magnetic resonance, infrared radiation, ultraviolet–visible, and electronic circular dichroism spectroscopy. Dibohemamine I (1) exhibited selective cytotoxic effects against the cancer cell lines 786-O and GBC-SD among the 18 cell lines evaluated, with the half-inhibitory concentration values of 3.24 ± 0.20 and 7.36 ± 0.41 μM, respectively.

Graphical Abstract