Grewiifopenes A–K, bioactive clerodane diterpenoids from Casearia grewiifolia Vent.

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2024年9月14日

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Phanruethai Pailee,
Paratchata Batsomboon,
Wiriya Yaosanit,
Theerawat Thananthaisong,
Chulabhorn Mahidol,
Poonsakdi Ploypradith,
Nanthawan Reuk-ngam,
Panita Khlaychan,
Supanna Techasakul,
Somsak Ruchirawat,
Vilailak Prachyawarakorn

摘要

Eleven novel clerodane-type diterpenoids, grewiifopenes A–K (1–4 and 12–18), along with nine known compounds (5–11, 19, and 20) were purified from the dichloromethane extract of the twigs and stems of Casearia grewiifolia Vent. (Salicaceae). Their spectroscopic data, including the NMR, HRESIMS, and electronic circular dichroism calculations were employed to completely characterize and elucidate the chemical structures and absolute configurations. The clerodane diterpenoids possessing a 6-OH group and no substitution at C-7 exhibited greater cytotoxic activity than others, with their IC₅₀ values ranging from 0.3 to 2.9 μM. Isocaseamembrin E (7) exhibited antibacterial activity against Staphylococcus aureus, while isocaseamembrin E (7), corymbulosin X (8), caseargrewiin A (9), kurzipene A (10), and balanspene F (11) exhibited antibacterial activity against Bacillus cereus.

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