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<p>Tumor lysis syndrome (TLS) is a&#xa0;serious complication in (hemato-)oncology patients caused by the massive breakdown of tumor cells. This may lead to acute renal insufficiency, electrolyte disturbances, cardiac arrhythmias and even sudden death. In addition, there is an increased risk of uric acid stone formation. For urolithiasis, urologists are regularly involved in the treatment that focuses on drainage and/or stone removal. However, a&#xa0;conservative approach preventing and targeting TLS with medication can be effective. Alkalinizing the urine in the acute phase is risky and may further impair kidney function. Early recognition of TLS by means of collaboration between urologists and (hemato-)oncologists is crucial for the effective treatment of these patients.</p>

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Case report. Urolithiase bij patiënten met tumorlysissyndroom: valkuilen vanuit een urologisch perspectief

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月16日

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  • Anton Cuypers,
  • Marten R. Nijziel,
  • Rik de Jongh

摘要

Tumor lysis syndrome (TLS) is a serious complication in (hemato-)oncology patients caused by the massive breakdown of tumor cells. This may lead to acute renal insufficiency, electrolyte disturbances, cardiac arrhythmias and even sudden death. In addition, there is an increased risk of uric acid stone formation. For urolithiasis, urologists are regularly involved in the treatment that focuses on drainage and/or stone removal. However, a conservative approach preventing and targeting TLS with medication can be effective. Alkalinizing the urine in the acute phase is risky and may further impair kidney function. Early recognition of TLS by means of collaboration between urologists and (hemato-)oncologists is crucial for the effective treatment of these patients.