Het patroon van lokaal recidief na prostatectomie op PSMA PET/CT-scan

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2024年3月12日

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Floor H. E. Staal,
Walter Noordzij,
Jorinde Janssen,
Daniëla E. Oprea-Lager,
Antoine M. Engelen,
Evert J. van Limbergen,
Robert Jan Smeenk,
Marianne A. A. de Jong,
Tom C. G. Budiharto,
Inge Jacobs,
M. A. Dorien Haverkort,
Charlotte L. Brouwer,
Kelvin Ng Wei Siang,
Johannes A. Langendijk,
J. Fred Verzijlbergen,
Igle Jan de Jong,
Shafak Aluwini

摘要

This study aimed to describe the local recurrence (LR) pattern in post-prostatectomy prostate cancer patients using PSMA PET/CT scans. We retrospectively collected 103 PSMA PET/CT scans from patients with suspected LR across nine medical centres. Anonymized scans underwent review by an expert nuclear medicine physician. After review, on 83 PSMA PET/CT scans, 93 lesions were identified as a LR. The predominant LR location (56%) was found within 2 cm cranial to the penile bulb. Additionally, 24 LR (26%) were observed > 2 cm cranial to the penile bulb and caudal to the top of the pubic bone. Only 17 LR (18%) occurred cranial to the symphysis pubis. These findings contribute to the understanding of LR pattern post-prostatectomy, potentially optimizing accurate salvage radiotherapy to the prostate bed.