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<p>ZW10 (Zeste White 10) plays an essential role in maintaining chromosomal stability during cell division. However, its contribution to tumor development, particularly in colon adenocarcinoma (COAD) remains poorly understood. This study aimed to comprehensively investigate the expression pattern, epigenetic regulation, immune relevance, prognostic significance, and molecular interactions of ZW10 in colon cancer. We analyzed transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) to assess ZW10 expression across cancer types. Differential expression, survival analysis, DNA methylation profiling, immune cell correlation, and co-expression network analyses were conducted using bioinformatics and statistical approaches including TIMER, TNMplot, ULCAN, GSCA, and GEPIA2. Kaplan–Meier survival analysis was performed to evaluate the prognostic significance of ZW10 in COAD. ZW10 was significantly upregulated in COAD and showed strong associations with advanced tumor stage, nodal metastasis, and TP53 mutation (<i>p</i> &lt; 0.001). Promoter methylation analysis revealed increased methylation levels in tumors compared to normal tissues (<i>p</i> &lt; 0.001), suggesting potential epigenetic regulation. ZW10 expression positively correlated with various immune cell infiltrates, indicating the role of ZW10 in modulating the tumor microenvironment. High ZW10 levels were associated with reduced overall survival (HR = 1.23; <i>p</i> = 0.045), whereas higher ZW10 levels correlated with improved relapse-free survival (HR = 0.62; <i>p</i> = 1.7e-05). Gene co-expression analysis indicated that ZW10 is associated with key oncogenic pathways regulating mitosis and cell proliferation. ZW10 may contribute to colon cancer progression and represent a context-dependent biomarker and therapeutic target, though its prognostic value requires further validation.</p>

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Bioinformatic analysis identifies ZW10 as a potential prognostic biomarker and therapeutic target in human colon cancer

  • 期刊论文

  • 发表日期：

    2026年5月14日

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  • Sm Faysal Bellah,
  • SMSaker Billah

摘要

ZW10 (Zeste White 10) plays an essential role in maintaining chromosomal stability during cell division. However, its contribution to tumor development, particularly in colon adenocarcinoma (COAD) remains poorly understood. This study aimed to comprehensively investigate the expression pattern, epigenetic regulation, immune relevance, prognostic significance, and molecular interactions of ZW10 in colon cancer. We analyzed transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) to assess ZW10 expression across cancer types. Differential expression, survival analysis, DNA methylation profiling, immune cell correlation, and co-expression network analyses were conducted using bioinformatics and statistical approaches including TIMER, TNMplot, ULCAN, GSCA, and GEPIA2. Kaplan–Meier survival analysis was performed to evaluate the prognostic significance of ZW10 in COAD. ZW10 was significantly upregulated in COAD and showed strong associations with advanced tumor stage, nodal metastasis, and TP53 mutation (p < 0.001). Promoter methylation analysis revealed increased methylation levels in tumors compared to normal tissues (p < 0.001), suggesting potential epigenetic regulation. ZW10 expression positively correlated with various immune cell infiltrates, indicating the role of ZW10 in modulating the tumor microenvironment. High ZW10 levels were associated with reduced overall survival (HR = 1.23; p = 0.045), whereas higher ZW10 levels correlated with improved relapse-free survival (HR = 0.62; p = 1.7e-05). Gene co-expression analysis indicated that ZW10 is associated with key oncogenic pathways regulating mitosis and cell proliferation. ZW10 may contribute to colon cancer progression and represent a context-dependent biomarker and therapeutic target, though its prognostic value requires further validation.