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<p>A complicated and life-threatening non-communicable medical disorder, diabetes mellitus affects and kills mankind all over the world. Its prevalence can be marked by its occurrence in 1 in 11 adults, with mostly (90%) one of its two types, type 2 diabetes. Around 80% of the adult diabetics belong to the developing countries. India is one among the top ten countries with the largest number of people with diabetes mellitus. This trend alarms the world, and it is going to be a big threat unless there is effective action. Diabetes mellitus is associated with high mortality rate because it increases the risk of cardiovascular illnesses, kidney impairment, and neuropathy. The risks and side effects of the current treatments for diabetes mellitus demand the search for newer and safer drugs for the treatment of Diabetes. For millennia, traditional herbal medicines have been used to treat variety of ailments. Despite their long tradition, their authenticity, safety, and effectiveness must be confirmed in order to create safer and more modern medications. Discovering new plant secondary metabolites became crucial due to the sharp rise in the demand for diabetes medications. The majority of herbal diabetic medications and secondary metabolites reported to be functioning by modulating insulin signaling pathways, translocation of the GLUT-4 receptor, activating the PPARγ, or through immunomodulatory and/or anti-inflammatory actions. Many of these plant products bring about anti-diabetic potential by regulating lipid metabolism. Medicinal herbs, including extracts and bioactive molecules, are effective in lowering blood glucose levels. This mini review provides a compilation of research on the engagement of the different plant-derived antidiabetics in the recent past. First of all, this review highlights the molecular aspects of insulin signaling and secondly the bioactive compounds of different plant species that exert antidiabetic effect. This review also provides insights to researchers on the development of newer, eco-friendly and safer antidiabetic drugs out of these plants.</p>

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Mini review on antidiabetic botanicals: molecular insights and future prospects

  • 期刊论文

  • 发表日期：

    2026年3月16日

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  • G. S. Anantha Selvi,
  • T. P. Kumari Pushpa Rani,
  • A. Doss,
  • J. Aranganayaki,
  • N. Ahamed Kabir,
  • R. P. Praveen Pole,
  • S. Satheesh

摘要

A complicated and life-threatening non-communicable medical disorder, diabetes mellitus affects and kills mankind all over the world. Its prevalence can be marked by its occurrence in 1 in 11 adults, with mostly (90%) one of its two types, type 2 diabetes. Around 80% of the adult diabetics belong to the developing countries. India is one among the top ten countries with the largest number of people with diabetes mellitus. This trend alarms the world, and it is going to be a big threat unless there is effective action. Diabetes mellitus is associated with high mortality rate because it increases the risk of cardiovascular illnesses, kidney impairment, and neuropathy. The risks and side effects of the current treatments for diabetes mellitus demand the search for newer and safer drugs for the treatment of Diabetes. For millennia, traditional herbal medicines have been used to treat variety of ailments. Despite their long tradition, their authenticity, safety, and effectiveness must be confirmed in order to create safer and more modern medications. Discovering new plant secondary metabolites became crucial due to the sharp rise in the demand for diabetes medications. The majority of herbal diabetic medications and secondary metabolites reported to be functioning by modulating insulin signaling pathways, translocation of the GLUT-4 receptor, activating the PPARγ, or through immunomodulatory and/or anti-inflammatory actions. Many of these plant products bring about anti-diabetic potential by regulating lipid metabolism. Medicinal herbs, including extracts and bioactive molecules, are effective in lowering blood glucose levels. This mini review provides a compilation of research on the engagement of the different plant-derived antidiabetics in the recent past. First of all, this review highlights the molecular aspects of insulin signaling and secondly the bioactive compounds of different plant species that exert antidiabetic effect. This review also provides insights to researchers on the development of newer, eco-friendly and safer antidiabetic drugs out of these plants.