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<p>The meridian theory has been practiced since ancient times, but its underlying mechanisms remain unclear. This study investigated the relationship of TE3 and BL65 acupoints to related cervical regions by skin temperature (ST) adaptation under an infrared sensor. Thirty healthy participants were recruited into a self-control pilot trial and randomly allocated into three groups undergoing three crossover intervention sessions. The ST was measured at the cervical cutaneous region of the Greater Yang (CRG) and Lesser Yang meridians (CRL). Secondary outcomes included vital signs, attributed psychological factors, and adverse events. The results showed that manipulating TE3 and BL65 significantly increased the cervical ST (<i>p</i> &lt; 0.05, linear mixed-effects model) compared to SP3 acupoints. In contrast, the ST changes at CRG were not significantly different from CRL (<i>p</i> &gt; 0.05, linear mixed-effect model). Psychological attributes showed minimal impact on the change of cervical ST. No severe adverse event was recorded. Our findings suggest a relationship between TB3 and BL65 and the cervical region, beyond the concept of the meridian network. Further studies need to be performed to confirm the effect of these acupoints on patients with cervical disorders, which might reinforce physicians to prescribe distal acupoints in the clinical context.</p> Graphical abstract <p></p>

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Beyond the meridian theory: the cervical skin temperature alteration effect of Shu-stream acupoints—a randomized, self-controlled pilot trial

  • 期刊论文

  • 发表日期：

    2026年1月31日

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  • Loc Cong Dai Tran,
  • Sang Nguyen-Cao Phan,
  • Hung Thanh Ngo,
  • Minh-Anh Nguyen-Ngo-Le,
  • Diem Ngoc Hong Tran,
  • Bay Thi Nguyen

摘要

The meridian theory has been practiced since ancient times, but its underlying mechanisms remain unclear. This study investigated the relationship of TE3 and BL65 acupoints to related cervical regions by skin temperature (ST) adaptation under an infrared sensor. Thirty healthy participants were recruited into a self-control pilot trial and randomly allocated into three groups undergoing three crossover intervention sessions. The ST was measured at the cervical cutaneous region of the Greater Yang (CRG) and Lesser Yang meridians (CRL). Secondary outcomes included vital signs, attributed psychological factors, and adverse events. The results showed that manipulating TE3 and BL65 significantly increased the cervical ST (p < 0.05, linear mixed-effects model) compared to SP3 acupoints. In contrast, the ST changes at CRG were not significantly different from CRL (p > 0.05, linear mixed-effect model). Psychological attributes showed minimal impact on the change of cervical ST. No severe adverse event was recorded. Our findings suggest a relationship between TB3 and BL65 and the cervical region, beyond the concept of the meridian network. Further studies need to be performed to confirm the effect of these acupoints on patients with cervical disorders, which might reinforce physicians to prescribe distal acupoints in the clinical context.

Graphical abstract