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<p>The study aimed to investigate the wound-healing activity and antimicrobial properties of <i>Cryptolepis sanguinolenta</i> root and its main alkaloid, cryptolepine. <i>C. sanguinolenta</i> was extracted with water, and cryptolepine was isolated from the root of the plant. The antimicrobial properties of <i>C. sanguinolenta</i> and cryptolepine were evaluated against some selected microorganisms. Excision wounds were made on the dorsal area of Sprague-Dawley rats, which were then treated with the prepared aqueous cream formulations containing <i>C. sanguinolenta</i> (2.5%, 5%, and 10% w/w) and cryptolepine (0.1% and 0.3%). Molecular docking was performed to predict the interaction between cryptolepine and test organisms. <i>C. sanguinolenta</i> and cryptolepine increased the sensitivity of the test organisms to the conventional drugs. The time-kill kinetic assay showed that <i>C. sanguinolenta</i> and cryptolepine possessed static activity. Wounds from rats treated with 10% w/w <i>C. sanguinolenta</i> and 0.1% and 0.3% w/w cryptolepine exhibited a significant reduction in wound size over the study period (<i>p</i> &lt; 0.05) compared to untreated wounds. Tissue histology showed no residual inflammation, marked epithelialization and collagen deposition and angiogenesis in 10% w/w <i>C. sanguinolenta</i>-treated wounds, 1% and 0.3% w/w cryptolepine-treated rat wounds. The findings of this study show that <i>C. sanguinolenta</i> and its isolated compound, cryptolepine, possess wound-healing and antimicrobial activity.</p>

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Cryptolepis sanguinolenta and cryptolepine as dual-action therapeutics: enhancing antimicrobial activity and promoting wound repair

  • 期刊论文

  • 发表日期：

    2026年1月10日

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  • Ahmed Wahab Obeng,
  • Theresa Appiah Agana,
  • Vivian Etsiapa Boamah,
  • Yaw Duah Boakye,
  • Erdi Can Aytar,
  • Francis Adu,
  • Christian Agyare

摘要

The study aimed to investigate the wound-healing activity and antimicrobial properties of Cryptolepis sanguinolenta root and its main alkaloid, cryptolepine. C. sanguinolenta was extracted with water, and cryptolepine was isolated from the root of the plant. The antimicrobial properties of C. sanguinolenta and cryptolepine were evaluated against some selected microorganisms. Excision wounds were made on the dorsal area of Sprague-Dawley rats, which were then treated with the prepared aqueous cream formulations containing C. sanguinolenta (2.5%, 5%, and 10% w/w) and cryptolepine (0.1% and 0.3%). Molecular docking was performed to predict the interaction between cryptolepine and test organisms. C. sanguinolenta and cryptolepine increased the sensitivity of the test organisms to the conventional drugs. The time-kill kinetic assay showed that C. sanguinolenta and cryptolepine possessed static activity. Wounds from rats treated with 10% w/w C. sanguinolenta and 0.1% and 0.3% w/w cryptolepine exhibited a significant reduction in wound size over the study period (p < 0.05) compared to untreated wounds. Tissue histology showed no residual inflammation, marked epithelialization and collagen deposition and angiogenesis in 10% w/w C. sanguinolenta-treated wounds, 1% and 0.3% w/w cryptolepine-treated rat wounds. The findings of this study show that C. sanguinolenta and its isolated compound, cryptolepine, possess wound-healing and antimicrobial activity.