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<p>Myrcene is a dietary monoterpene found in many plant species, mainly cannabis and citrus fruits. It is a food additive and pharmaceutical that serves as a flavoring and fragrance ingredient for the food and cosmetics industries. This monoterpene has been described as having anti-inflammatory properties. However, its activity against systemic inflammation (SI)-associated syndromes, which cause high mortality worldwide, remains unclear. In this study, we aimed to assess the activity of myrcene on thermoregulatory responses and inflammatory mediators against lipopolysaccharide (LPS)-induced SI. Male Wistar rats (230–280&#xa0;g) were treated with myrcene (7.5&#xa0;mg/kg, oral gavage) or vehicle (1% Tween 80, 10&#xa0;ml/kg) 30&#xa0;min before LPS (100&#xa0;μg/kg) or saline (1&#xa0;ml/kg). Deep body temperature was monitored using implanted data loggers, and blood samples were analyzed for systemic and central inflammatory markers using ELISA and multiplex assays. Statistical analysis was performed using two-way ANOVA, followed by Tukey's test (<i>p</i>&lt; 0.05). Myrcene treatment did not alter the temperature of saline-treated rats. In LPS-treated animals, myrcene significantly attenuated fever and reduced systemic tumor necrosis factor-α (TNF-α) levels. Acute myrcene treatment modulated the immune response to LPS challenge by preventing fever and reducing TNF-α levels, suggesting its potential as an anti-inflammatory agent.</p> Graphical abstract <p></p>

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Myrcene suppressed fever by downregulating systemic TNF-α levels in acute LPS-induced systemic inflammation in rats

  • 期刊论文

  • 发表日期：

    2025年12月23日

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  • Maycon T. Emilio-Silva,
  • Vinicius P. Rodrigues,
  • Mariana M. Fioravanti,
  • Luiz G. S. Branco,
  • Clelia A. Hiruma-Lima

摘要

Myrcene is a dietary monoterpene found in many plant species, mainly cannabis and citrus fruits. It is a food additive and pharmaceutical that serves as a flavoring and fragrance ingredient for the food and cosmetics industries. This monoterpene has been described as having anti-inflammatory properties. However, its activity against systemic inflammation (SI)-associated syndromes, which cause high mortality worldwide, remains unclear. In this study, we aimed to assess the activity of myrcene on thermoregulatory responses and inflammatory mediators against lipopolysaccharide (LPS)-induced SI. Male Wistar rats (230–280 g) were treated with myrcene (7.5 mg/kg, oral gavage) or vehicle (1% Tween 80, 10 ml/kg) 30 min before LPS (100 μg/kg) or saline (1 ml/kg). Deep body temperature was monitored using implanted data loggers, and blood samples were analyzed for systemic and central inflammatory markers using ELISA and multiplex assays. Statistical analysis was performed using two-way ANOVA, followed by Tukey's test (p< 0.05). Myrcene treatment did not alter the temperature of saline-treated rats. In LPS-treated animals, myrcene significantly attenuated fever and reduced systemic tumor necrosis factor-α (TNF-α) levels. Acute myrcene treatment modulated the immune response to LPS challenge by preventing fever and reducing TNF-α levels, suggesting its potential as an anti-inflammatory agent.

Graphical abstract