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<p>Androgenetic alopecia is the main reason for seeking dermatological treatments in men. Consequently, natural sources with potential for hair revitalization, such as <i>Salvia rosmarinus</i> Spenn. (rosemary) essential oil, are under investigation. In this study, a film-forming spray incorporating rosemary essential oil was developed to promote hair density restoration. The essential oil was characterized using gas chromatography coupled with mass spectrometry, and three formulations were prepared for topical application in spray form: a negative control formulation consisting solely of an alcoholic solution with Eudragit and propylene glycol; a formulation loaded with 1.0% rosemary essential oil; and a positive control loaded with 0.25% finasteride. Physicochemical characterization of the formulations was conducted, and hair restoration density was evaluated in volunteers over 16&#xa0;weeks. The major compounds in the essential oil were α-pinene, 1,8-cineole, verbenone, and geraniol. The formulations were classified as adhesive and transparent. The incorporation of essential oil did not interfere with the drying time or the volume delivered, but it slightly increased the pH. However, the pH of the formulations remained stable over a 12-month storage period. The films showed a dense and thin structure; there was no skin permeation. Clinical results showed that the film-forming spray loaded with rosemary and the positive control increased capillary density. Therefore, the film-forming spray loaded with rosemary possesses characteristics suitable for topical application, with potential efficacy in treating alopecia by promoting hair density restoration.</p>

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Film-forming spray loaded with Salvia rosmarinus essential oil: preparation, characterization and successful treatment of alopecia by hair restoration density

  • 期刊论文

  • 发表日期：

    2025年4月17日

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  • Marcila Martins de Oliveira,
  • Mariana Dalmagro,
  • Mariana Moraes Pinc,
  • Mariana Caroline Maccari,
  • Camila da Silva,
  • Inara Staub Prochnau,
  • Kelen Menezes Flores Rossi de Aguiar,
  • Ezilda Jacomassi,
  • Daniela de Cássia Faglioni Boleta-Ceranto,
  • Jaqueline Hoscheid

摘要

Androgenetic alopecia is the main reason for seeking dermatological treatments in men. Consequently, natural sources with potential for hair revitalization, such as Salvia rosmarinus Spenn. (rosemary) essential oil, are under investigation. In this study, a film-forming spray incorporating rosemary essential oil was developed to promote hair density restoration. The essential oil was characterized using gas chromatography coupled with mass spectrometry, and three formulations were prepared for topical application in spray form: a negative control formulation consisting solely of an alcoholic solution with Eudragit and propylene glycol; a formulation loaded with 1.0% rosemary essential oil; and a positive control loaded with 0.25% finasteride. Physicochemical characterization of the formulations was conducted, and hair restoration density was evaluated in volunteers over 16 weeks. The major compounds in the essential oil were α-pinene, 1,8-cineole, verbenone, and geraniol. The formulations were classified as adhesive and transparent. The incorporation of essential oil did not interfere with the drying time or the volume delivered, but it slightly increased the pH. However, the pH of the formulations remained stable over a 12-month storage period. The films showed a dense and thin structure; there was no skin permeation. Clinical results showed that the film-forming spray loaded with rosemary and the positive control increased capillary density. Therefore, the film-forming spray loaded with rosemary possesses characteristics suitable for topical application, with potential efficacy in treating alopecia by promoting hair density restoration.