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<p>HSPA8, a crucial molecular chaperone, has been implicated in the promotion of cancer across various malignancies. The clinical significance of HSPA8 in gastric cancer (GC) and its molecular contribution to tumour progression are unknown. Sequencing data from the GEO and TCGA databases, along with independent immunohistochemical data, revealed that HAPA8 was upregulated in GC tissues and was associated with tumour stage. HSPA8 knockdown decreased GC cell proliferation, migration, and invasion in vitro. According to the results of transcriptome sequencing and western blotting, HSPA8 suppression primarily affects the Wnt/β-catenin signalling and glycolysis pathways. In nude mice, HSPA8 knockdown drastically reduced tumour growth. The results of the current study validated the oncogenic function of HSPA8 in GC. Its overexpression is linked to GC development and poor clinicopathology.</p>

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HSPA8 promotes the progression of gastric cancer by activating the canonical Wnt pathway and glycolysis

  • 期刊论文

  • 发表日期：

    2025年12月26日

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  • Xiaoyi Shi,
  • Peng Ge,
  • Yalan Luo,
  • Jianzhong Liu,
  • Xiao Shi,
  • Jingwen Zhang,
  • Aixia Gong

摘要

HSPA8, a crucial molecular chaperone, has been implicated in the promotion of cancer across various malignancies. The clinical significance of HSPA8 in gastric cancer (GC) and its molecular contribution to tumour progression are unknown. Sequencing data from the GEO and TCGA databases, along with independent immunohistochemical data, revealed that HAPA8 was upregulated in GC tissues and was associated with tumour stage. HSPA8 knockdown decreased GC cell proliferation, migration, and invasion in vitro. According to the results of transcriptome sequencing and western blotting, HSPA8 suppression primarily affects the Wnt/β-catenin signalling and glycolysis pathways. In nude mice, HSPA8 knockdown drastically reduced tumour growth. The results of the current study validated the oncogenic function of HSPA8 in GC. Its overexpression is linked to GC development and poor clinicopathology.