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<p><i>Hylocereus undatus</i> has attracted a special attention for its remarkable health benefits such as help mitigate oxidative stress by safeguarding cells against damage from free radicals, thereby lowering the risk of chronic conditions like cardiovascular diseases, cancer, and neurodegenerative disorders, which can be attributed to the large number of bioactive compounds it contains. This study aimed to optimize phenolic compounds extraction from <i>Hylocereus undatus</i> peel and pulp cultivated in Tunisia using ultrasound-assisted extraction. A central composite design (CCD) and methodology surface response (RSM) were used to examine the effects of three factors: extraction time (6.96–17.04&#xa0;min), temperature (33.18–66.81&#xa0;°C) and solvent -to- material ratio (13.18–46.81&#xa0;ml/g). The optimal extraction conditions for bioactive compounds from <i>Hylocereus undatus</i> peel were defined to be: 11.84&#xa0;min, 52.20&#xa0;°C, achieving maximum responses of 6&#xa0;mg GAE/g DW, 5.36&#xa0;mg QE/g DW, 163.75&#xa0;µg/ml and 490.81 µM BHT/g DW. However, the best conditions for <i>Hylocereus undatus</i> pulp were determined to be: 48.13&#xa0;°C, 13.07&#xa0;min 31.18 mL/g. Under these conditions, the pulp exhibited the highest values for total phenolic content (TPC: 6.74&#xa0;mg GAE/g DW), total flavonoid content (TFC: 5.42&#xa0;mg QE/g DW), DPPH radical scavenging activity (127.86&#xa0;µg/mL), and ferric reducing antioxidant power (FRAP: 497 µM BHT/g DW). The main phenolic compounds identified in <i>Hylocereus undatus</i> pulp and peel extracts were tyrosol, ellagic as well as vanillic acids and catechin. The results of this investigation revealed that ultrasound-assisted extraction is an efficient and rapid technique for enhancing phenolic compound recovery through cavitation-induced cell disruption. Moreover, its potential economic feasibility and environmental sustainability could facilitate successful industrial application. In addition, extracts obtained from <i>Hylocereus undatus</i> pulp and peel serve as excellent natural sources of antioxidant compounds, making them suitable for applications in the food and pharmaceutical industries.</p>

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Ultrasound extraction of antioxidant phenolic compounds from Hylocereus undatus growing in Tunisia: optimization, antioxidant activities, and HPLC-DAD analysis

  • 期刊论文

  • 发表日期：

    2026年8月4日

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  • Wissal Ayouni,
  • Amira Yahyaoui,
  • Fatma Saadi,
  • Ridha Ben Salem,
  • Ghayth Rigane

摘要

Hylocereus undatus has attracted a special attention for its remarkable health benefits such as help mitigate oxidative stress by safeguarding cells against damage from free radicals, thereby lowering the risk of chronic conditions like cardiovascular diseases, cancer, and neurodegenerative disorders, which can be attributed to the large number of bioactive compounds it contains. This study aimed to optimize phenolic compounds extraction from Hylocereus undatus peel and pulp cultivated in Tunisia using ultrasound-assisted extraction. A central composite design (CCD) and methodology surface response (RSM) were used to examine the effects of three factors: extraction time (6.96–17.04 min), temperature (33.18–66.81 °C) and solvent -to- material ratio (13.18–46.81 ml/g). The optimal extraction conditions for bioactive compounds from Hylocereus undatus peel were defined to be: 11.84 min, 52.20 °C, achieving maximum responses of 6 mg GAE/g DW, 5.36 mg QE/g DW, 163.75 µg/ml and 490.81 µM BHT/g DW. However, the best conditions for Hylocereus undatus pulp were determined to be: 48.13 °C, 13.07 min 31.18 mL/g. Under these conditions, the pulp exhibited the highest values for total phenolic content (TPC: 6.74 mg GAE/g DW), total flavonoid content (TFC: 5.42 mg QE/g DW), DPPH radical scavenging activity (127.86 µg/mL), and ferric reducing antioxidant power (FRAP: 497 µM BHT/g DW). The main phenolic compounds identified in Hylocereus undatus pulp and peel extracts were tyrosol, ellagic as well as vanillic acids and catechin. The results of this investigation revealed that ultrasound-assisted extraction is an efficient and rapid technique for enhancing phenolic compound recovery through cavitation-induced cell disruption. Moreover, its potential economic feasibility and environmental sustainability could facilitate successful industrial application. In addition, extracts obtained from Hylocereus undatus pulp and peel serve as excellent natural sources of antioxidant compounds, making them suitable for applications in the food and pharmaceutical industries.