<p>Plant immunity is a multilayered defense mechanism by which plants fight against pathogenic organisms. Numerous studies have shown the influence of the nonsense-mediated messenger RNA decay (NMD) pathway to modulate plant immune responses. While NMD has been extensively studied for maintaining gene expression and cellular homeostasis, its role in plant immunity is still an emerging area of research. By controlling the over-expression of immune receptors, NMD prevent autoimmunity development in plants, thereby maintaining plant health. Many recent studies have revealed that, NMD activity in plants gets suppressed during pathogen attack, which helps in stabilizing NMD sensitive transcripts of immune receptors and their expression, enhancing plant immunity against microbial pathogens. The dynamic interactions between NMD and plant immune response genes expression indicate that pathogens might exploit this pathway. Upon attack by microbial pathogen, NMD activity in plants get down regulated to enhance the expression of immune-boosting genes, but this down regulation of NMD may have negative impact on normal growth and development. NMD interacts with key immune signaling pathways modulating its function. However, the precise molecular mechanisms linking NMD with plant immunity is not fully clear. Therefore, a comprehensive understanding of the precise mechanism of NMD in modulating plant immunity could help in developing disease resistant plant variety with balanced growth and development. This review shed light on current understanding of the association between plant immunity and NMD pathway to deal pathogen attacks.</p>