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Introduction <p>Collagen peptides are widely used to support skin health, but the immunological mechanisms mediating such effects remain unclear. So, this study investigated the effects of bioactive collagen peptide (BCP) supplementation on facial wrinkles, skin biophysical properties, and systemic levels of transforming growth factor-beta (TGF-β) and Klotho in sedentary middle-aged women.</p> Methods <p>This randomized controlled trial included 119 healthy, sedentary women, aged 35–55&#xa0;years who were randomly assigned to control, Col 2.5&#xa0;g, or Col 10&#xa0;g groups. Daily oral supplementation for 12&#xa0;weeks consisted of either 2.5&#xa0;g/day or 10&#xa0;g/day of BCP (Peptpure<sup>®</sup>), or participants were allocated to a non-supplemented control group.</p> Results <p>Supplementation with 10&#xa0;g/day of BCP significantly reduced the number (<i>p</i> &lt; 0.0002) and length (<i>p</i> &lt; 0.0424) of wrinkles. Both collagen groups improved skin elasticity (<i>p</i> &lt; 0.0321 for 2.5&#xa0;g; <i>p</i> &lt; 0.0065 for 10&#xa0;g) and hydration (<i>p</i> &lt; 0.0471 for 2.5&#xa0;g; <i>p</i> &lt; 0.0037 for 10&#xa0;g). Plasma TGF-β levels were significantly elevated in the 2.5&#xa0;g group (<i>p</i> &lt; 0.0026) and 10&#xa0;g group (<i>p</i> &lt; 0.0001) compared with controls, as well as Klotho levels for both collagen groups (<i>p</i> &lt; 0.0016 and <i>p</i> &lt; 0.0001, respectively).</p> Conclusions <p>A 12-week course of Peptpure<sup>®</sup> BCP supplementation improved facial skin health, underlined by increased systemic levels of TGF-β and Klotho, suggesting activation of regenerative and antiaging pathways.</p> Trial Registration <p>ClinicalTrials.gov identifier: NCT06971029.</p>

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Immune-Modulatory Effects of Bioactive Collagen Peptides Improve Skin Health in Middle-Aged Women

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月27日

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  • Rosa Helena Ramos Paula-Vieira,
  • Sandra Regina Dias,
  • Anamei Silva-Reis,
  • Meiry Souza Moura-Maia,
  • Nycole Vieira Ramos-Gomes,
  • Kananda Jesus-Silva,
  • Yasmim Rodrigues Oliveira-Leal,
  • Laura Thaís Castro-Pimentel,
  • Wany Soares Fagundes Carvalho,
  • Flavia Melo,
  • José Luis Rodrigues Martins,
  • André Luis Lacerda Bachi,
  • Rodolfo P. Vieira

摘要

Introduction

Collagen peptides are widely used to support skin health, but the immunological mechanisms mediating such effects remain unclear. So, this study investigated the effects of bioactive collagen peptide (BCP) supplementation on facial wrinkles, skin biophysical properties, and systemic levels of transforming growth factor-beta (TGF-β) and Klotho in sedentary middle-aged women.

Methods

This randomized controlled trial included 119 healthy, sedentary women, aged 35–55 years who were randomly assigned to control, Col 2.5 g, or Col 10 g groups. Daily oral supplementation for 12 weeks consisted of either 2.5 g/day or 10 g/day of BCP (Peptpure®), or participants were allocated to a non-supplemented control group.

Results

Supplementation with 10 g/day of BCP significantly reduced the number (p < 0.0002) and length (p < 0.0424) of wrinkles. Both collagen groups improved skin elasticity (p < 0.0321 for 2.5 g; p < 0.0065 for 10 g) and hydration (p < 0.0471 for 2.5 g; p < 0.0037 for 10 g). Plasma TGF-β levels were significantly elevated in the 2.5 g group (p < 0.0026) and 10 g group (p < 0.0001) compared with controls, as well as Klotho levels for both collagen groups (p < 0.0016 and p < 0.0001, respectively).

Conclusions

A 12-week course of Peptpure® BCP supplementation improved facial skin health, underlined by increased systemic levels of TGF-β and Klotho, suggesting activation of regenerative and antiaging pathways.

Trial Registration

ClinicalTrials.gov identifier: NCT06971029.