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Introduction <p>Dermocosmetics are widely used to complement dermatologic care, yet context-specific guidance remains limited for populations with Fitzpatrick skin types III–V. We convened a national expert panel to generate transparent, reproducible recommendations across ten common clinical scenarios.</p> Methods <p>Egyptian dermatologists participated in round&#xa0;1 (national survey, <i>n</i> = 601) and round&#xa0;2 (expert panel, <i>n</i> = 16), both with anonymous ratings and inter-round feedback, using the RAND/UCLA appropriateness method (median bands 1–3/4–6/7–9; disagreement index (DI) = interpercentile range (IPR)/IPR adjusted for symmetry (IPRAS); DI &gt; 1.0 = disagreement). Per-item outputs included median, P30, P70, IPR (30–70), asymmetry Index (AI), IPRAS, DI, and final category (appropriate/uncertain/inappropriate). We additionally benchmarked classifications against prior consensus, guidelines, and key evidence frameworks.</p> Results <p>Across ten vignettes and 30 ingredients (30 ingredients × 10 scenarios = 300 items; multiple raters per item in round&#xa0;1), 158 (52.7%) items were appropriate (median ≥ 7; DI ≤ 1.0), 135 (45.0%) were uncertain, and 7 (2.3%) were inappropriate. Photoprotection had the highest appropriateness across scenarios (broad-spectrum/tinted SPF), with a small number of DI-flagged uncertain exceptions. Hydration/barrier agents (e.g., hyaluronic acid, peptides, ceramides) were appropriate in stress-aging, post-laser, and post-procedure care. Pigment modulators (tranexamic acid, arbutin, niacinamide, vitamin&#xa0;C, glabridin) were appropriate in melasma/post-inflammatory hyperpigmentation and chronic sun-induced pigmentation. Classical retinoids were inappropriate for postpartum/breastfeeding and immediate post-procedure; lower-irritancy retinoid esters were context-dependent. Botanicals showed inconsistent support. Panel disagreement (DI &gt; 1.0) declined from 38.3% in round&#xa0;1 to 15.7% (47/300) in round&#xa0;2. Patterns largely aligned with prior consensus; visible-light-mitigating photoprotection and timing-specific retinoid use were emphasized for darker phototypes.</p> Conclusion <p>We provide a transparent, regionally relevant framework for dermocosmetic ingredient selection. Sun protection and barrier support are foundational; pigment modulators are scenario-specific; retinoids require selective use; botanicals remain adjunctive.</p>

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Egyptian National Consensus on Dermocosmetic Ingredient Selection Across Common Dermatology Scenarios: A RAND/UCLA Appropriateness Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月15日

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  • Mahmoud A. Rageh,
  • Wael M. Seoudy,
  • Mohamed F. Abozeid,
  • Abeer Mohamed Elkholy,
  • Alaa E. A. Moubasher,
  • Amany Mohammad Abdel-Latif,
  • Dalia Abdel Aziz Attallah,
  • Essamelden M. Mohamed,
  • Hanan Abdelrady Assaf,
  • Hanan Sabry,
  • Mohamed Mahmoud Nasr,
  • Mohamed Saad Hegazy,
  • Nahla Hunter,
  • Nehal Zuelfakkar,
  • Nermeen Ibrahim Bedair,
  • Noha Ezzat Mohammed,
  • Sameh F. Abdelkodous,
  • Yasser Mostafa Gohary,
  • Sara M. Mohy

摘要

Introduction

Dermocosmetics are widely used to complement dermatologic care, yet context-specific guidance remains limited for populations with Fitzpatrick skin types III–V. We convened a national expert panel to generate transparent, reproducible recommendations across ten common clinical scenarios.

Methods

Egyptian dermatologists participated in round 1 (national survey, n = 601) and round 2 (expert panel, n = 16), both with anonymous ratings and inter-round feedback, using the RAND/UCLA appropriateness method (median bands 1–3/4–6/7–9; disagreement index (DI) = interpercentile range (IPR)/IPR adjusted for symmetry (IPRAS); DI > 1.0 = disagreement). Per-item outputs included median, P30, P70, IPR (30–70), asymmetry Index (AI), IPRAS, DI, and final category (appropriate/uncertain/inappropriate). We additionally benchmarked classifications against prior consensus, guidelines, and key evidence frameworks.

Results

Across ten vignettes and 30 ingredients (30 ingredients × 10 scenarios = 300 items; multiple raters per item in round 1), 158 (52.7%) items were appropriate (median ≥ 7; DI ≤ 1.0), 135 (45.0%) were uncertain, and 7 (2.3%) were inappropriate. Photoprotection had the highest appropriateness across scenarios (broad-spectrum/tinted SPF), with a small number of DI-flagged uncertain exceptions. Hydration/barrier agents (e.g., hyaluronic acid, peptides, ceramides) were appropriate in stress-aging, post-laser, and post-procedure care. Pigment modulators (tranexamic acid, arbutin, niacinamide, vitamin C, glabridin) were appropriate in melasma/post-inflammatory hyperpigmentation and chronic sun-induced pigmentation. Classical retinoids were inappropriate for postpartum/breastfeeding and immediate post-procedure; lower-irritancy retinoid esters were context-dependent. Botanicals showed inconsistent support. Panel disagreement (DI > 1.0) declined from 38.3% in round 1 to 15.7% (47/300) in round 2. Patterns largely aligned with prior consensus; visible-light-mitigating photoprotection and timing-specific retinoid use were emphasized for darker phototypes.

Conclusion

We provide a transparent, regionally relevant framework for dermocosmetic ingredient selection. Sun protection and barrier support are foundational; pigment modulators are scenario-specific; retinoids require selective use; botanicals remain adjunctive.