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Introduction <p>To date, several reports demonstrated improved markers of subclinical atherosclerosis in patients with psoriasis treated with biologics. However, data on the antiatherogenic effect of IL23 inhibitors are sparse. Herein, we sought to assess the impact of 1-year treatment with an interleukin (IL)-17 or IL-23 inhibitor on arterial stiffness in patients with moderate-to-severe psoriasis.</p> Methods <p>This observational cohort study included patients with moderate-to-severe psoriasis treated with either an IL-17 inhibitor or an IL-23 inhibitor or a conventional systemic agent/apremilast (control group) for 52 weeks. The primary outcome was the evaluation of changes in carotid-femoral pulse wave velocity (PWV) and augmentation index normalized to 75 beats/min (AIx75) after 24 and 52 weeks. Secondary outcomes were the comparison of change in PWV and AIx75 between the study groups and the assessment of psoriasis disease severity scores and in ankle-brachial index (ABI).</p> Results <p>In total, 66 patients (39 male/27 female), with a mean [standard deviation (SD)] age of 56 (13.1) years, were included; 21 received an IL-17 inhibitor, 29 an IL-23 inhibitor, and 16 a conventional systemic agent or apremilast (control group). PWV and AIx75 improved in all groups at weeks 24 and 52. However, a statistically significant reduction of PWV was observed only in the IL23 group as early as at week 24 (<i>p</i> &lt; 0.001). AIx75 was reduced significantly in the IL17 group at week 24 and in both IL-17 and IL-23 groups at week 52 (<i>p</i> &lt; 0.001 and <i>p</i> = 0.014, respectively). The reduction of PWV and AIx75 at week 52 did not reach the level of statistical significance in the control group and was statistically comparable between the IL-17 and IL-23 groups.</p> Conclusions <p>Both IL-23 and IL-17 inhibition exhibited comparable improvement of arterial stiffness in patients with psoriasis. Further studies are needed to evaluate the long-term impact of biologics on the cardiovascular status of these patients.</p> <p>Retrospectively registered ClinicalTrials.gov identifier: NCT07169682. A Graphical abstract is available for this article.</p> Graphical Abstract <p></p>

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Effects of IL17/23 Inhibitors on Markers of Subclinical Atherosclerosis in Patients with Psoriasis: An Observational Study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月8日

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  • Aikaterini Tsiogka,
  • Stergios Soulaidopoulos,
  • Stamatios Gregoriou,
  • Natalia Rompoti,
  • Pantelis Panagakis,
  • Marina Papoutsaki,
  • Panagiotis Kostakis,
  • George Kontochristopoulos,
  • Konstantinos Tsioufis,
  • Charalambos Vlachopoulos,
  • Alexander Stratigos,
  • Dimitrios Rigopoulos

摘要

Introduction

To date, several reports demonstrated improved markers of subclinical atherosclerosis in patients with psoriasis treated with biologics. However, data on the antiatherogenic effect of IL23 inhibitors are sparse. Herein, we sought to assess the impact of 1-year treatment with an interleukin (IL)-17 or IL-23 inhibitor on arterial stiffness in patients with moderate-to-severe psoriasis.

Methods

This observational cohort study included patients with moderate-to-severe psoriasis treated with either an IL-17 inhibitor or an IL-23 inhibitor or a conventional systemic agent/apremilast (control group) for 52 weeks. The primary outcome was the evaluation of changes in carotid-femoral pulse wave velocity (PWV) and augmentation index normalized to 75 beats/min (AIx75) after 24 and 52 weeks. Secondary outcomes were the comparison of change in PWV and AIx75 between the study groups and the assessment of psoriasis disease severity scores and in ankle-brachial index (ABI).

Results

In total, 66 patients (39 male/27 female), with a mean [standard deviation (SD)] age of 56 (13.1) years, were included; 21 received an IL-17 inhibitor, 29 an IL-23 inhibitor, and 16 a conventional systemic agent or apremilast (control group). PWV and AIx75 improved in all groups at weeks 24 and 52. However, a statistically significant reduction of PWV was observed only in the IL23 group as early as at week 24 (p < 0.001). AIx75 was reduced significantly in the IL17 group at week 24 and in both IL-17 and IL-23 groups at week 52 (p < 0.001 and p = 0.014, respectively). The reduction of PWV and AIx75 at week 52 did not reach the level of statistical significance in the control group and was statistically comparable between the IL-17 and IL-23 groups.

Conclusions

Both IL-23 and IL-17 inhibition exhibited comparable improvement of arterial stiffness in patients with psoriasis. Further studies are needed to evaluate the long-term impact of biologics on the cardiovascular status of these patients.

Retrospectively registered ClinicalTrials.gov identifier: NCT07169682. A Graphical abstract is available for this article.

Graphical Abstract