Scholarlink

Introduction <p>Chronic pruritus (CP; lasting ≥ 6&#xa0;weeks) is a prevalent symptom with diverse underlying conditions, including chronic liver diseases (CLD), chronic kidney diseases (CKD) and atopic dermatitis (AD). CP is linked to a substantial physical, psychological and socioeconomic burden. Despite guideline-recommend therapies, there remains a lack of comprehensive understanding regarding the specific needs, treatment goals and patient-reported outcomes (PRO) of patients with CP across these aetiologies.</p> Methods <p>To address this gap, this retrospective cohort study analysed anonymized electronic health records from a specialized pruritus centre in Germany, focusing on three matched sub-cohorts, which were compiled from a total cohort of 1998 patients with CLD, CKD and AD to systematically compare disease burden, and treatment priorities.</p> Results <p>Patients with CLD and CKD exhibited significantly higher psychological distress compared to patients with AD, while patients with AD demonstrated greater quality of life impairment. Treatment goals were largely aligned across all patient groups, with symptom relief, diagnostic clarity and confidence in therapy emerging as top priorities. Significant correlations between patient needs, QoL impairment, levels of anxiety and depression and pruritus intensity were observed across all sub-cohorts.</p> Conclusions <p>These results highlight the need for holistic, patient-centred management strategies that address both the physical and psychological aspects of CP.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative Analysis of Patient-Reported Outcomes in Chronic Pruritus: Patients with Chronic Liver or Kidney Diseases Exhibit Higher Psychological Distress than Those with Atopic Dermatitis

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月11日

查看全文
  • Svenja Royeck,
  • Christian Mess,
  • Angelika Weigel,
  • Bernd Löwe,
  • Anne Toussaint,
  • Christoph Schramm,
  • Meike Shedden Mora,
  • Tobias B. Huber,
  • Claudia Zeidler,
  • Felix Witte,
  • Matthias Augustin,
  • Konstantin Agelopoulos,
  • Henning Wiegmann,
  • Johannes B. Oehm,
  • Stefan W. Schneider,
  • Sonja Ständer

摘要

Introduction

Chronic pruritus (CP; lasting ≥ 6 weeks) is a prevalent symptom with diverse underlying conditions, including chronic liver diseases (CLD), chronic kidney diseases (CKD) and atopic dermatitis (AD). CP is linked to a substantial physical, psychological and socioeconomic burden. Despite guideline-recommend therapies, there remains a lack of comprehensive understanding regarding the specific needs, treatment goals and patient-reported outcomes (PRO) of patients with CP across these aetiologies.

Methods

To address this gap, this retrospective cohort study analysed anonymized electronic health records from a specialized pruritus centre in Germany, focusing on three matched sub-cohorts, which were compiled from a total cohort of 1998 patients with CLD, CKD and AD to systematically compare disease burden, and treatment priorities.

Results

Patients with CLD and CKD exhibited significantly higher psychological distress compared to patients with AD, while patients with AD demonstrated greater quality of life impairment. Treatment goals were largely aligned across all patient groups, with symptom relief, diagnostic clarity and confidence in therapy emerging as top priorities. Significant correlations between patient needs, QoL impairment, levels of anxiety and depression and pruritus intensity were observed across all sub-cohorts.

Conclusions

These results highlight the need for holistic, patient-centred management strategies that address both the physical and psychological aspects of CP.