Scholarlink

Introduction <p>Ablative fractional CO<sub>2</sub> laser treatment (AFCO<sub>2</sub>) can cause immediate erythema, pain, and complications such as prolonged erythema and post-inflammatory hyperpigmentation. This study investigated whether the use of a serum before and after AFCO<sub>2</sub> could accelerate skin recovery and relieve complications.</p> Methods <p>This randomized controlled trial included 72 healthy Chinese women with acne scars who intended to undergo AFCO<sub>2</sub>; 64 (32 in each group) completed the study and were included in the analysis. The participants in the serum group applied the study serum for 2&#xa0;weeks in the preoperative (D0 and D14) and post-treatment stages (D32 and D39), with additional product usage of standard products, including standard cleanser, moisturizer, and sunscreen, for all participants (both groups). Transepidermal water loss (TEWL), skin hydration, and skin qualities were evaluated throughout the entire study. Clinical assessment was conducted at D0 (baseline and time immediately after product application); D14; D15 (directly after procedure treatment); D16, D18, D22, and D25 (1&#xa0;day, 3&#xa0;days, 7&#xa0;and 10&#xa0;days after CO<sub>2</sub> laser treatment); and during the post-treatment period at D32 and D39 (1 and 2&#xa0;weeks after self-recovery).</p> Results <p>TEWL improvement was significantly better in the serum group than in the control group throughout the study (<i>p</i> &lt; 0.001), including pre-treatment (<i>p</i> = 0.043), self-recovery (D15–D31) (<i>p</i> &lt; 0.001), and post-treatment (<i>p</i> = 0.027) stages. In the post-treatment stage, the improvement in skin hydration with the serum was significantly better than in the control group (<i>p</i> &lt; 0.001). The serum group showed significantly better improvements in smoothness (<i>p</i> = 0.001), brightness (<i>p</i> = 0.016), and overall healthy appearance (<i>p</i> = 0.001) compared with controls.</p> Conclusion <p>Peri-AFCO<sub>2</sub> application of the serum can facilitate faster postoperative recovery and can help reduce postoperative erythema and discomfort with satisfying tolerance. The use of the serum can enhance effectiveness and satisfaction with AFCO<sub>2</sub> treatment.</p> Trial registration <p>This trial was retrospectively registered on 30 June 2025: ISRCTN identifier ISRCTN60519611.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Efficacy and Tolerability of a Facial Serum Before and After Ablative Fractional Carbon Dioxide Laser: A Randomized Controlled Trial on Chinese Women

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年9月26日

查看全文
  • Jing Li,
  • Xingzuo Liu,
  • Zhiming Zhang,
  • Hequn Wang,
  • Jingbo Ma,
  • Yanwen Jiang,
  • Le Sheng,
  • Shumei Li,
  • Ji Zhang,
  • Xinrong Lin,
  • Kungchi Hsu,
  • Yidong Tu,
  • Andrew Steel,
  • Yan Wu,
  • Frederic Flament

摘要

Introduction

Ablative fractional CO2 laser treatment (AFCO2) can cause immediate erythema, pain, and complications such as prolonged erythema and post-inflammatory hyperpigmentation. This study investigated whether the use of a serum before and after AFCO2 could accelerate skin recovery and relieve complications.

Methods

This randomized controlled trial included 72 healthy Chinese women with acne scars who intended to undergo AFCO2; 64 (32 in each group) completed the study and were included in the analysis. The participants in the serum group applied the study serum for 2 weeks in the preoperative (D0 and D14) and post-treatment stages (D32 and D39), with additional product usage of standard products, including standard cleanser, moisturizer, and sunscreen, for all participants (both groups). Transepidermal water loss (TEWL), skin hydration, and skin qualities were evaluated throughout the entire study. Clinical assessment was conducted at D0 (baseline and time immediately after product application); D14; D15 (directly after procedure treatment); D16, D18, D22, and D25 (1 day, 3 days, 7 and 10 days after CO2 laser treatment); and during the post-treatment period at D32 and D39 (1 and 2 weeks after self-recovery).

Results

TEWL improvement was significantly better in the serum group than in the control group throughout the study (p < 0.001), including pre-treatment (p = 0.043), self-recovery (D15–D31) (p < 0.001), and post-treatment (p = 0.027) stages. In the post-treatment stage, the improvement in skin hydration with the serum was significantly better than in the control group (p < 0.001). The serum group showed significantly better improvements in smoothness (p = 0.001), brightness (p = 0.016), and overall healthy appearance (p = 0.001) compared with controls.

Conclusion

Peri-AFCO2 application of the serum can facilitate faster postoperative recovery and can help reduce postoperative erythema and discomfort with satisfying tolerance. The use of the serum can enhance effectiveness and satisfaction with AFCO2 treatment.

Trial registration

This trial was retrospectively registered on 30 June 2025: ISRCTN identifier ISRCTN60519611.