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Introduction <p>Acne pathogenesis is multifactorial, involving systemic factors including gut dysbiosis, hormones, and chronic inflammation. Probiotics, myoinositol, and plant-derived molecules may modulate acne by targeting these factors. The objective is to compare a synbiotic containing herbs against a myoinositol-based herbal supplement on how they influence acne, the gut microbiome, short chain fatty acids (SCFAs), and hormonal profiles.</p> Methods <p>This was an 8-week, randomized study involving 36 male and female patients aged 12 to 45&#xa0;years with non-cystic acne. Subjects received either a synbiotic or a myoinositol-based herbal supplement (MBHS). Acne lesions were counted, stool samples were collected for gut microbiome and SCFA analyses, and hormone collections were performed at baseline, 4, and 8&#xa0;weeks.</p> Results <p>Several gut bacteria increased by at least threefold at both week&#xa0;4 and 8 in the synbiotic (<i>Erysipelatoclostridium merdavium</i>, <i>Blautia argi</i>, <i>Faecalibacterium prausnitzii</i>, <i>Prevotella copri</i>, <i>Streptococcus sp001556435</i>, <i>Blautia sp900541955</i>) and MBHS group (<i>Megamonas funiformis</i>, <i>Ligilactobacillus ruminis</i>, <i>Prevotella ssp015074785</i>, <i>Prevotella copri</i>, <i>Gca-900199835 sp900176495</i>). Acne lesion counts decreased significantly in both groups at week&#xa0;4 (<i>p</i> &lt; 0.0001) and week&#xa0;8 (synbiotic, <i>p</i> &lt; 0.0001; MBHS, <i>p</i> &lt; 0.0001). There were significant and trending increases in stool and plasma SCFAs in both cohorts at week&#xa0;4 and 8. After 8&#xa0;weeks of MBHS, 17-OHP and androstenedione significantly decreased from 27.3 to 11.3&#xa0;pg/ml (<i>p</i> = 0.001) and 94.9 to 68.0&#xa0;pg/ml (<i>p</i> = 0.04), respectively.</p> Conclusion <p>Both the synbiotic and MBHS improved gut health, augmented SCFAs, and reduced lesion counts in those with non-cystic acne. The MBHS may act by reducing hormone levels of 17-OHP and androstenedione.</p> Clinical Trial Registration <p><a href="http://www.clinicaltrials.gov">www.clinicaltrials.gov</a> (NCT05919810).</p>

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Prospective Comparative Study of an Oral Synbiotic and a Myoinositol-Based Herbal Supplement in Modifying Hormone Levels and the Gut Microbiome in Non-cystic Acne

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月18日

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  • Mildred Min,
  • Nasima Afzal,
  • Jessica Maloh,
  • Ajay S. Dulai,
  • Nabeel Ahmad,
  • David Pinzauti,
  • Raja K. Sivamani

摘要

Introduction

Acne pathogenesis is multifactorial, involving systemic factors including gut dysbiosis, hormones, and chronic inflammation. Probiotics, myoinositol, and plant-derived molecules may modulate acne by targeting these factors. The objective is to compare a synbiotic containing herbs against a myoinositol-based herbal supplement on how they influence acne, the gut microbiome, short chain fatty acids (SCFAs), and hormonal profiles.

Methods

This was an 8-week, randomized study involving 36 male and female patients aged 12 to 45 years with non-cystic acne. Subjects received either a synbiotic or a myoinositol-based herbal supplement (MBHS). Acne lesions were counted, stool samples were collected for gut microbiome and SCFA analyses, and hormone collections were performed at baseline, 4, and 8 weeks.

Results

Several gut bacteria increased by at least threefold at both week 4 and 8 in the synbiotic (Erysipelatoclostridium merdavium, Blautia argi, Faecalibacterium prausnitzii, Prevotella copri, Streptococcus sp001556435, Blautia sp900541955) and MBHS group (Megamonas funiformis, Ligilactobacillus ruminis, Prevotella ssp015074785, Prevotella copri, Gca-900199835 sp900176495). Acne lesion counts decreased significantly in both groups at week 4 (p < 0.0001) and week 8 (synbiotic, p < 0.0001; MBHS, p < 0.0001). There were significant and trending increases in stool and plasma SCFAs in both cohorts at week 4 and 8. After 8 weeks of MBHS, 17-OHP and androstenedione significantly decreased from 27.3 to 11.3 pg/ml (p = 0.001) and 94.9 to 68.0 pg/ml (p = 0.04), respectively.

Conclusion

Both the synbiotic and MBHS improved gut health, augmented SCFAs, and reduced lesion counts in those with non-cystic acne. The MBHS may act by reducing hormone levels of 17-OHP and androstenedione.

Clinical Trial Registration

www.clinicaltrials.gov (NCT05919810).