Introduction <p>Ablative carbon dioxide fractional laser (CO₂ AFL) can alleviate static wrinkles; however, its use in East Asian populations can predispose them to postinflammatory hyperpigmentation (PIH). We aimed to explore the optimum energy and coverage parameters of CO₂ AFL for treating static periorbital wrinkles in a Chinese population and to minimize PIH incidence.</p> Methods <p>In total, 30 patients with static periorbital wrinkles were recruited. The PIH intervention side (1% hydroquinone cream every night on one periorbital area for each patient 1&#xa0;month before and from the 8th day to 1&#xa0;month after each treatment) and group (group A: 15‒20&#xa0;mJ, 5%; group B: 10‒12.5&#xa0;mJ, 15%; and group C: 12.5‒15&#xa0;mJ, 10%) were determined randomly. The patients underwent two sessions of CO₂ AFL at 3-month intervals. Follow-ups were conducted until 6&#xa0;months after the last treatment.</p> Results <p>Overall, 20 participants (48.1 ± 13.1&#xa0;years) completed all follow-ups without any serious complications. The application of hydroquinone significantly reduced PIH (<i>p</i> = 0.02). Both the investigators’ and patients’ visual evaluations demonstrated a consistent efficacy rate of 68.2% without differences between groups. The Fitzpatrick wrinkle score significantly decreased compared with pre-treatment (<i>p</i> &lt; 0.01); however, a significant reduction only in group B at 3&#xa0;months (<i>p</i> = 0.016) and 6&#xa0;months (<i>p</i> = 0.001) post-treatment was observed. Groups B and C demonstrated significant reductions in superficial and deep wrinkles and pigmentation (<i>p</i> &lt; 0.01).</p> Conclusions <p>CO₂ AFL effectively reduced static periorbital wrinkles in the Chinese population. Low energy combined with high-density coverage was the most efficacious. The application of hydroquinone significantly reduced PIH incidence.</p> Trial Registration <p>Chinese Clinical Trial Registration no. ChiCTR2400087320 (date of trial registration: 25 July 2024).</p>