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<p>Nanohole arrays have emerged as promising platforms for various optical applications due to their unique light-matter interactions and tunable resonant properties. In this study, we investigate the influence of nanohole radius and surrounding refractive index on the resonant wavelength shifts of nanohole arrays through rigorous numerical simulations. The presented results reveal a systematic exploration of nanohole arrays with radii ranging from 50&#xa0;nm to 80&#xa0;nm and varying refractive index changes in the surrounding medium. A clear correlation emerges between nanohole radius and the magnitude of resonant wavelength shifts, demonstrating enhanced sensitivity with increasing nanohole size. Furthermore, incremental changes in the surrounding refractive index led to predictable shifts in resonant wavelengths, highlighting the potential utility of nanohole arrays as highly responsive platforms for sensing applications. These findings provide valuable insights for the design and optimization of nanohole-based devices tailored for specific optical sensing and detection requirements. In this study, we explore the potential of nanohole arrays as advanced sensing platforms for the detection of SARS-CoV-2. Specifically, plasmonic nanohole biosensors with a 50&#xa0;nm radius achieve a sensitivity of 148.41&#xa0;nm/RIU and a figure of merit (FoM) of 15.11, while those with 60&#xa0;nm, 70&#xa0;nm, and 80&#xa0;nm radii exhibit sensitivities of 171.21, 230.82, and 250.50&#xa0;nm/RIU, with corresponding FoMs of 11.48, 9.51, and 7.07, respectively. These results illustrate a trade-off between sensitivity and spectral resolution, highlighting the need to tailor nanohole sizes to specific application requirements for optimal performance in biosensing. The detection and analysis of SARS-CoV-2 using nanohole-based sensors pose significant challenges in balancing sensitivity and spectral resolution.</p>

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A Novel Design and Analysis of a Highly Sensitive Optical Biosensor Based on Plasmonic Nano Cavity for Detection of SARS-CoV-2

  • 期刊论文

  • 发表日期：

    2026年2月11日

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  • Hamid Heidarzadeh

摘要

Nanohole arrays have emerged as promising platforms for various optical applications due to their unique light-matter interactions and tunable resonant properties. In this study, we investigate the influence of nanohole radius and surrounding refractive index on the resonant wavelength shifts of nanohole arrays through rigorous numerical simulations. The presented results reveal a systematic exploration of nanohole arrays with radii ranging from 50 nm to 80 nm and varying refractive index changes in the surrounding medium. A clear correlation emerges between nanohole radius and the magnitude of resonant wavelength shifts, demonstrating enhanced sensitivity with increasing nanohole size. Furthermore, incremental changes in the surrounding refractive index led to predictable shifts in resonant wavelengths, highlighting the potential utility of nanohole arrays as highly responsive platforms for sensing applications. These findings provide valuable insights for the design and optimization of nanohole-based devices tailored for specific optical sensing and detection requirements. In this study, we explore the potential of nanohole arrays as advanced sensing platforms for the detection of SARS-CoV-2. Specifically, plasmonic nanohole biosensors with a 50 nm radius achieve a sensitivity of 148.41 nm/RIU and a figure of merit (FoM) of 15.11, while those with 60 nm, 70 nm, and 80 nm radii exhibit sensitivities of 171.21, 230.82, and 250.50 nm/RIU, with corresponding FoMs of 11.48, 9.51, and 7.07, respectively. These results illustrate a trade-off between sensitivity and spectral resolution, highlighting the need to tailor nanohole sizes to specific application requirements for optimal performance in biosensing. The detection and analysis of SARS-CoV-2 using nanohole-based sensors pose significant challenges in balancing sensitivity and spectral resolution.