<p>Pyrethroids have been documented to accumulate in animal bodies. Multiple experimental studies suggest potential disruption of male reproductive function, yet findings remain inconsistent. Therefore, a comprehensive synthesis is required to clarify overall reproductive risks. Herein, we aim to quantitatively synthesize evidence from mammalian studies investigating the impact of pyrethroid exposure on male reproductive outcomes. A systematic search of Google Scholar, EMBASE, PubMed, and Scopus was conducted. Data extraction included species, exposure characteristics, outcomes, and methodological quality. Meta-analyses were conducted using standardized mean differences. Heterogeneity was evaluated using I² and Q statistics. Subgroup and sensitivity analyses were performed to explore sources of variation. Sixty-two studies were selected, which primarily involved rats, with oral exposure as the dominant route. Geographically, studies originated mainly from India, Egypt, and Tunisia. Across pooled analyses, pyrethroid exposure showed no statistically significant overall effect on sperm count, motility, viability, testes weight, or testosterone levels. Leave-one-out analyses demonstrated robust but consistent pooled effects. Rats showed stronger negative trends than mice. Overall, the pooled SMD for all reproductive outcomes combined was –2.30 (95% CI –3.80 to –0.81, p = 0.003). Our study demonstrates that pyrethroid exposure can adversely influence male reproductive endpoints. More standardized, mechanistic, and dose-controlled mammalian studies are needed to refine risk assessment.</p>