Background <p>Although fluoride-based remineralization techniques have dominated preventive dentistry for the past century, new and innovative nanomaterial approaches have revolutionized the industry, as a unique and diverse range of these materials are now readily available to assist in the remineralization of tooth enamel surfaces. </p> Objective <p>This study aimed to investigate the effectiveness of platinum nanoparticles in preventing dental caries and their impact on human tooth enamel.</p> Materials and methods <p>Platinum nanomaterials prepared in deionized water were applied with laser energy and pulses to human tooth enamel in the laboratory, where the surface hardness of the tooth enamel was analyzed using a Vickers microhardness tester, and the morphological changes in the ultrastructure of the enamel were evaluated using field emission scanning electron microscopy. Using UV-visible absorption spectroscopy, X-ray diffraction (XRD), Field emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM), the physical properties of platinum nanoparticles created by ablation in liquid media were evaluated, and the effect of varying concentrations on both dental caries bacteria (S.mutans) and the toxicity of these materials was studied. The study showed that they are suitable for human use.</p> Results <p>The results showed an increase in the microhardness of the teeth compared to the tooth in which the nanomaterial was implanted. The energy dispersive spectroscopy (EDS) device also showed a change in the chemical composition of the tooth after implanting the nanomaterial inside the tooth enamel.</p> Conclusion <p>It was found that the nanomaterial is a remineralization of the tooth enamel, and therefore it can be considered an alternative to oral sodium fluoride mouthwash.</p>