<p>Twenty-first century and interpersonal skills have been identified as one of the initial 22 key areas for consideration in the ongoing comprehensive review of the International Convention for Standards of Training, Certification and Watchkeeping for Seafarers (STCW). The term twenty-first century skills has become ubiquitous among scholars and practitioners yet still has no widely accepted definition in the literature. In the maritime context, it is acknowledged that twenty-first century skills are critical for seafarers and for inclusion in maritime education and training curricula. This study adopted a mixed method approach entailing a scoping review of extant twenty-first century skills literature and a modified Skill Technology Forecast (STF), involving a survey and workshop, to collect seafarers’ opinions on the skills that are most critical for the maritime context. The 10 most important twenty-first century skills obtained from the scoping review were considered by participants with seafaring experience, who deliberated on and assessed their anticipated necessity (over 90%; 50–90%; 10–50%) for officers and ratings in the short to mid-term, and identified which prevailing trends were most strongly associated with the skills in question. Trends were derived from the 22 areas of the Comprehensive Review of the STCW Convention and clustered into five overarching categories of maritime trends: digitalization, decarbonization, safe working environment, mental health, and effective and efficient training. Based on the input from the participants, the prioritization of twenty-first century skills for officers as well as ratings is presented and implications for maritime education and training are discussed.</p>