Background <p>Cirrhosis with diabetes presents major self-management challenges. While WeChat-based education shows potential, its efficacy and RBP1’s role are unclear.</p> Objective <p>To explore the efficacy of WeChat-based health education on glycemic control, diabetes self-management, medication adherence, and liver function in patients with liver cirrhosis complicated by type 2 diabetes (T2D), and to investigate the potential of retinol binding protein 1 (RBP1) as an exploratory biomarker for the intervention effects, so as to provide clinical evidence for the chronic disease management of this population.</p> Methods <p>Patients with liver cirrhosis and T2D were randomly assigned to the control group (conventional care) and the study group (conventional care plus WeChat-based health education), with the latter involving personalized health delivery, real-time consultation, and data tracking with feedback. Bioinformatics analysis and least absolute shrinkage and selection operator regression were used to screen differentially expressed genes, and a support vector machine (SVM) model was applied to analyze key clinical indicators.</p> Results <p>Bioinformatics identified retinol binding protein 1 (RBP1) as significant. After 3&#xa0;months, groups showed significant differences (<i>p</i> &lt; 0.05) in fasting glucose, HbA1c, serum albumin, total bilirubin, SDSCA, MMAS-8 scores, and RBP1 expression. SVM analysis highlighted SDSCA as critical; RBP1 had a non-linear link to intervention and strong predictive power.</p> Conclusion <p>WeChat-based health education may potentially improve self-management capacity, glycemic control, medication adherence, and liver function in patients with liver cirrhosis and T2D, and might be statistically associated with the modulation of RBP1 expression, with this association being exploratory and non-causal. This intervention approach may potentially serve as a convenient and efficient supplementary strategy for the chronic disease management of this specific population.</p>