The prevalence of latent autoimmune diabetes misdiagnosed with type 2 diabetes mellites among adult patients in Jordan: A cross-sectional study
摘要
Latent autoimmune diabetes adults (LADA), also referred to as type 1.5 diabetes, represents a more gradually progressing form of autoimmune diabetes. Latent autoimmune diabetes adults (LADA), as Type 1 Diabetes Mellitus (T1DM), is marked by reduced insulin secretion and is initially diagnosed as Type 2 Diabetes Mellitus.
ObjectiveAssess the frequency of patients with clinical characteristics of LADA (presumed LADA) based on clinical features and identified disparities between type 2 diabetes mellitus and latent autoimmune diabetes adult groups.
MethodsThis cross-sectional study was carried out in the endocrinology department of Al-Salt Hospital, Amman, from 30th May to 28th December 2022 using a data collection sheet to gather clinical and demographic information from patients.
ResultsThe study enrolled 400 participants, with an average age of 49.5 ± 10.9 years. Out of the total, 103 participants (25.75%) exhibited definitive clinical characteristics of latent autoimmune diabetes adults (presumed LADA). Analysis of HbA1C, education level, chronic illness, and insulin consumption revealed no statistically significant differences between patients diagnosed with type 2 diabetes mellitus and those with latent autoimmune diabetes adults. However, Type 2 diabetes mellitus patients exhibited a higher frequency of family history of diabetes (64%) than latent autoimmune diabetes adult patients (36%), and autoimmune thyroid disease was observed in 11% of latent autoimmune diabetes adults patients.
ConclusionThe findings emphasize the high prevalence of clinical characteristics of LADA (presumed LADA) in Jordan and importance of accurately identifying latent autoimmune diabetes adults among type 2 diabetes mellitus patients to ensure appropriate management.