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Background <p>People with young-onset diabetes comprise a heterogeneous group, with etiologies including classic type 1 or type 2 diabetes mellitus, pancreatic diabetes and the rarer maturity-onset diabetes of young (MODY) and some remain unclassified.</p> Objective <p>The present study was planned to study the clinical characteristics, presentation &amp; progression of those with young onset diabetes &amp; to classify them into existing diabetes subtypes and identify the heterogeneity within.</p> Methods <p>The present study was conducted on 89 subjects with diabetes onset between 6 months to 30 years of age. Subjects were classified into preexisting diabetes types, while the rest were labeled as unclassified.</p> Results <p>The commonest type of diabetes was type 1 (52%), followed by type 2 (22.5%), pancreatic diabetes (9%) and MODY (3.4%). Twelve (13.48%) subjects remained unclassified. Fifteen percent of subjects among type 1 were found to be insulin resistant and 45% among type 2 were insulin sensitive. Unclassified group had mixed patterns.</p> Conclusion <p>The varied clinical presentation and disease progression underscores the need for a more appropriate classification of diabetes in a clinical setting so as to decide on optimal modes of treatment and follow- up.</p>

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Study of heterogeneity in clinical phenotypes and etiology of young-onset diabetes mellitus

  • 期刊论文

  • 发表日期：

    2025年9月6日

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  • Pooja Tiwari,
  • Uma Kaimal Saikia,
  • Ashok Krishna Bhuyan,
  • Abhamoni Baro

摘要

Background

People with young-onset diabetes comprise a heterogeneous group, with etiologies including classic type 1 or type 2 diabetes mellitus, pancreatic diabetes and the rarer maturity-onset diabetes of young (MODY) and some remain unclassified.

Objective

The present study was planned to study the clinical characteristics, presentation & progression of those with young onset diabetes & to classify them into existing diabetes subtypes and identify the heterogeneity within.

Methods

The present study was conducted on 89 subjects with diabetes onset between 6 months to 30 years of age. Subjects were classified into preexisting diabetes types, while the rest were labeled as unclassified.

Results

The commonest type of diabetes was type 1 (52%), followed by type 2 (22.5%), pancreatic diabetes (9%) and MODY (3.4%). Twelve (13.48%) subjects remained unclassified. Fifteen percent of subjects among type 1 were found to be insulin resistant and 45% among type 2 were insulin sensitive. Unclassified group had mixed patterns.

Conclusion

The varied clinical presentation and disease progression underscores the need for a more appropriate classification of diabetes in a clinical setting so as to decide on optimal modes of treatment and follow- up.