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Background <p>Diabetes mellitus (DM) and its associated complications are a global health burden, necessitating the identification of novel diagnostic and therapeutic targets. Klotho, a protein with anti-aging properties, has gained attention as a promising candidate due to its multifunctional roles in aging, metabolism, oxidative stress regulation, and cellular protection.</p> Objective <p>This review will discuss Klotho’s potential as a diagnostic and therapeutic marker in DM and its complications,&#xa0;with an emphasis on Klotho gene polymorphisms associated with diabetic complications.</p> Methods <p>This review summarizes the findings from studies published until 2025 and written in English on Klotho’s role in DM and its complications. Relevant literature was gathered from PubMed and Google Scholar, focusing on studies examining Klotho levels, gene polymorphisms, and therapeutic implications. Keywords included “Klotho,” “diabetes,” “diabetic complications,” “diabetic nephropathy,” “ diabetic neuropathy,” “diabetic retinopathy,” “diabetic cardiovascular complications,” “diabetic liver disease,” and “diabetic foot syndrome.”</p> Results <p>Evidence implied that reduced α-Klotho is associated with diabetes progression and its complications, including nephropathy, retinopathy, neuropathy, and cardiovascular diseases. Some polymorphisms of the Klotho gene influence susceptibility to diabetes and its complications. The identification of Klotho gene polymorphisms provides valuable insights into personalized medicine approaches for managing diabetes. The presence of conflicting reports regarding Klotho levels in diabetic patients highlights the need for standardized assessment methods. Further research is needed to establish Klotho measurement techniques, explore its therapeutic potential, and conduct large-scale clinical trials to validate its efficacy in managing diabetic complications.</p> Conclusion <p>Klotho is emerging as a promising biomarker and therapeutic target in DM. Further research should focus on clarifying its regulatory mechanisms and clinical applicability to improve patient outcomes.</p>

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Klotho: A possible diagnostic biomarker and therapeutic target in diabetes complications

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Alireza Hejrati,
  • Tahereh Zabihi,
  • Sajedeh Riazi,
  • Fatemeh Sarv

摘要

Background

Diabetes mellitus (DM) and its associated complications are a global health burden, necessitating the identification of novel diagnostic and therapeutic targets. Klotho, a protein with anti-aging properties, has gained attention as a promising candidate due to its multifunctional roles in aging, metabolism, oxidative stress regulation, and cellular protection.

Objective

This review will discuss Klotho’s potential as a diagnostic and therapeutic marker in DM and its complications, with an emphasis on Klotho gene polymorphisms associated with diabetic complications.

Methods

This review summarizes the findings from studies published until 2025 and written in English on Klotho’s role in DM and its complications. Relevant literature was gathered from PubMed and Google Scholar, focusing on studies examining Klotho levels, gene polymorphisms, and therapeutic implications. Keywords included “Klotho,” “diabetes,” “diabetic complications,” “diabetic nephropathy,” “ diabetic neuropathy,” “diabetic retinopathy,” “diabetic cardiovascular complications,” “diabetic liver disease,” and “diabetic foot syndrome.”

Results

Evidence implied that reduced α-Klotho is associated with diabetes progression and its complications, including nephropathy, retinopathy, neuropathy, and cardiovascular diseases. Some polymorphisms of the Klotho gene influence susceptibility to diabetes and its complications. The identification of Klotho gene polymorphisms provides valuable insights into personalized medicine approaches for managing diabetes. The presence of conflicting reports regarding Klotho levels in diabetic patients highlights the need for standardized assessment methods. Further research is needed to establish Klotho measurement techniques, explore its therapeutic potential, and conduct large-scale clinical trials to validate its efficacy in managing diabetic complications.

Conclusion

Klotho is emerging as a promising biomarker and therapeutic target in DM. Further research should focus on clarifying its regulatory mechanisms and clinical applicability to improve patient outcomes.