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Background <p>Diabetes mellitus (DM) is a metabolic disease with a high incidence and serious harm to human health in China. Early diagnosis of diabetes is still based on a fasting plasma glucose (FPG) threshold set by the World Health Organization (WHO) in China due to the lack of local data.</p> Objective <p>We aimed to explore the optimal cut-off value of FPG in the diagnosis of diabetes in Chinese.</p> Methods <p>We retrospectively analyzed the data of 12,254 patients admitted to our hospital from January 2008 to December 2023 who underwent oral glucose tolerance test (OGTT). Fasting plasma glucose and 2-h postprandial blood glucose were obtained. They were grouped according to whether or not they were diagnosed with diabetes. Receiver operating curve (ROC) was drawn for the relationship between DM and FPG, and the optimal cut-off value of FPG for diagnosing DM was obtained.</p> Results <p>The optimal FPG cut-off value for diagnosing DM was 6.675&#xa0;mmol/L, the maximum area under the curve (AUC) was 0.922, and the predicted sensitivity and specificity of DM were 81.70% and 87.60%, respectively.</p> Conclusion <p>The adoption of FPG 6.675&#xa0;mmol/L as the new upper limit is more conducive to the early diagnosis and treatment of diabetes.</p>

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Optimizing the critical value of fasting plasma glucose for accurate diagnosis of diabetes mellitus in Chinese: A population study

  • 期刊论文

  • 发表日期：

    2025年6月27日

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  • Ying Xu,
  • Jinliang Cai,
  • Jingyi Zhang,
  • Wenjian Shi,
  • Wenye Jiao,
  • Xiaolu Zhang,
  • Dongmei Wang,
  • Lin Liu

摘要

Background

Diabetes mellitus (DM) is a metabolic disease with a high incidence and serious harm to human health in China. Early diagnosis of diabetes is still based on a fasting plasma glucose (FPG) threshold set by the World Health Organization (WHO) in China due to the lack of local data.

Objective

We aimed to explore the optimal cut-off value of FPG in the diagnosis of diabetes in Chinese.

Methods

We retrospectively analyzed the data of 12,254 patients admitted to our hospital from January 2008 to December 2023 who underwent oral glucose tolerance test (OGTT). Fasting plasma glucose and 2-h postprandial blood glucose were obtained. They were grouped according to whether or not they were diagnosed with diabetes. Receiver operating curve (ROC) was drawn for the relationship between DM and FPG, and the optimal cut-off value of FPG for diagnosing DM was obtained.

Results

The optimal FPG cut-off value for diagnosing DM was 6.675 mmol/L, the maximum area under the curve (AUC) was 0.922, and the predicted sensitivity and specificity of DM were 81.70% and 87.60%, respectively.

Conclusion

The adoption of FPG 6.675 mmol/L as the new upper limit is more conducive to the early diagnosis and treatment of diabetes.