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Objective <p>In the present study, the levels of four predominant gut bacterial phyla were compared between pregnant with gestational diabetes and healthy mothers and their relationship with the dietary inflammatory index was investigated.</p> Methods <p>Twenty pregnant women with diabetes diagnosed at 24–28 weeks of pregnancy based on glucose tolerance test and 40 healthy pregnant women with normal glucose results were selected. Stool samples were collected to assess the four phyla including <i>Firmicutes</i>, <i>Bacteroidetes</i>, <i>Actinobacteria</i>, and <i>Proteobacteria</i>. Bacterial DNA was extracted and <i>16S rRNA</i> gene amplification was performed by qPCR using universal bacterial primers. Dietary information was collected using a food frequency questionnaire (FFQ) and the dietary inflammatory index, adjusted for energy, was calculated.</p> Results <p>The dietary inflammatory index was significantly higher in women with gestational diabetes than the healthy (<i>p</i> = 0.02). The intestinal <i>Actinobacteria</i> population showed a significant difference between the two groups (<i>p</i> = 0.04). An inverse correlation was observed between fasting (<i>p</i> = 0.04) and 1-h (<i>p</i> = 0.01) blood glucose with <i>Actinobacteria</i> population. Height showed a significant effect on the population of <i>Proteobacteria</i> and <i>Bacteroidetes</i> (OR = 0.36, <i>p</i> = 0.007, 95%CI = 0.017, 0.02 and OR = 0.23, 95%CI = 0.04, 0.004, <i>p</i> = 0.04).</p> Conclusions <p>Increased fasting and 1-h blood sugar levels were associated with a decrease in the population of intestinal <i>Actinobacteria</i>, a beneficial phylum, in the studied population. Height was identified as an effective factor on the population of intestinal pathogens, which requires more extensive studies in this field. No statistically significant relationship was observed between the dietary inflammatory index and the studied phyla.</p>

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Relationship between dietary inflammatory index and predominant intestinal bacterial phylum in healthy pregnant women compared to gestational diabetes

  • 期刊论文

  • 发表日期：

    2025年4月15日

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  • Mahsa Nasiri,
  • Seyedeh Neda Mousavi,
  • Zahra Abbaspour Rad,
  • Siamak Heidarzadeh

摘要

Objective

In the present study, the levels of four predominant gut bacterial phyla were compared between pregnant with gestational diabetes and healthy mothers and their relationship with the dietary inflammatory index was investigated.

Methods

Twenty pregnant women with diabetes diagnosed at 24–28 weeks of pregnancy based on glucose tolerance test and 40 healthy pregnant women with normal glucose results were selected. Stool samples were collected to assess the four phyla including Firmicutes, Bacteroidetes, Actinobacteria, and Proteobacteria. Bacterial DNA was extracted and 16S rRNA gene amplification was performed by qPCR using universal bacterial primers. Dietary information was collected using a food frequency questionnaire (FFQ) and the dietary inflammatory index, adjusted for energy, was calculated.

Results

The dietary inflammatory index was significantly higher in women with gestational diabetes than the healthy (p = 0.02). The intestinal Actinobacteria population showed a significant difference between the two groups (p = 0.04). An inverse correlation was observed between fasting (p = 0.04) and 1-h (p = 0.01) blood glucose with Actinobacteria population. Height showed a significant effect on the population of Proteobacteria and Bacteroidetes (OR = 0.36, p = 0.007, 95%CI = 0.017, 0.02 and OR = 0.23, 95%CI = 0.04, 0.004, p = 0.04).

Conclusions

Increased fasting and 1-h blood sugar levels were associated with a decrease in the population of intestinal Actinobacteria, a beneficial phylum, in the studied population. Height was identified as an effective factor on the population of intestinal pathogens, which requires more extensive studies in this field. No statistically significant relationship was observed between the dietary inflammatory index and the studied phyla.