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Background <p>Gestational diabetes mellitus (GDM) disrupts maternal and fetal metabolic homeostasis. Brown adipose tissue-derived batokines and C-peptide play key roles in glucose regulation, but their involvement in GDM remains unclear. Investigating their interaction with fetal insulin production may provide novel insights into GDM pathophysiology.</p> Objective <p>To assess the levels of batokines Slit guidance ligand 2 protein (Slit2-C) and neuregulin-4 (NRG4) in maternal serum and C-peptide in cord serum in women with and without gestational diabetes mellitus (GDM) and their interaction on the fetal insulin production, considering maternal glycemic control.</p> Methods <p>A prospective case–control study was conducted with two groups of pregnant women: GDM (<i>n</i> = 58) and normal glucose tolerance (NGT) (<i>n</i> = 58). GDM diagnosis was based on a 75-g, 2-h oral glucose tolerance test. Maternal blood samples were collected on the day of cesarean section for measurement of circulating levels of maternal Slit2-C and NRG4 and cord C-peptide levels.</p> Results <p>The maternal Slit2-C and NRG4 levels were significantly lower in the GDM group compared to the NGT group. The GDM group exhibited increased cord serum C-peptide levels. A negative correlation was observed between maternal Slit2-C and NRG4 levels and cord C-peptide, suggesting a regulatory role of these batokines in fetal insulin secretion.</p> Conclusions <p>The study indicates a potential disruption in metabolic homeostasis in GDM, evidenced by altered levels of studied batokines and increased fetal insulin production. These findings highlight the significance of Slit2-C and NRG4 in GDM pathophysiology and emphasize the need for further research into their roles in fetal metabolic regulation.</p>

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The role of circulating maternal batokines Slit2-C and NRG4 and circulating cord C-peptide in gestational diabetes mellitus: A case–control study

  • 期刊论文

  • 发表日期：

    2025年2月13日

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  • Hatice Argun Atalmis,
  • Ebru Ayguler,
  • Hamdiye Acar,
  • Emine Yılmaz Guler,
  • Sevilay Yavuz Dogu,
  • Mehmet Bulur,
  • Sinem Tekin,
  • Filiz Yarsilikal Guleroglu,
  • Aydin Ocal,
  • Numan Cim,
  • Pelin Kulan,
  • Ali Cetin

摘要

Background

Gestational diabetes mellitus (GDM) disrupts maternal and fetal metabolic homeostasis. Brown adipose tissue-derived batokines and C-peptide play key roles in glucose regulation, but their involvement in GDM remains unclear. Investigating their interaction with fetal insulin production may provide novel insights into GDM pathophysiology.

Objective

To assess the levels of batokines Slit guidance ligand 2 protein (Slit2-C) and neuregulin-4 (NRG4) in maternal serum and C-peptide in cord serum in women with and without gestational diabetes mellitus (GDM) and their interaction on the fetal insulin production, considering maternal glycemic control.

Methods

A prospective case–control study was conducted with two groups of pregnant women: GDM (n = 58) and normal glucose tolerance (NGT) (n = 58). GDM diagnosis was based on a 75-g, 2-h oral glucose tolerance test. Maternal blood samples were collected on the day of cesarean section for measurement of circulating levels of maternal Slit2-C and NRG4 and cord C-peptide levels.

Results

The maternal Slit2-C and NRG4 levels were significantly lower in the GDM group compared to the NGT group. The GDM group exhibited increased cord serum C-peptide levels. A negative correlation was observed between maternal Slit2-C and NRG4 levels and cord C-peptide, suggesting a regulatory role of these batokines in fetal insulin secretion.

Conclusions

The study indicates a potential disruption in metabolic homeostasis in GDM, evidenced by altered levels of studied batokines and increased fetal insulin production. These findings highlight the significance of Slit2-C and NRG4 in GDM pathophysiology and emphasize the need for further research into their roles in fetal metabolic regulation.