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Background <p>Common comorbidities like type 2 diabetes mellitus and obesity along with their manifestations are linked to COVID-19 severity. Understanding perturbation in biochemical and endocrine parameters in these patients could help us define treatment modalities/guidelines for managing long COVID.</p> Objective <p>We attempted to comprehensively analyse various such markers to find their plausible influence on severity/mortality.</p> Methods <p>A total of 120 COVID-19 patients (mild and severe) were enrolled comprising four subgroups: COVID-19 only, COVID-19 with T2DM, COVID-19 with obesity and COVID-19 with T2DM and Obesity. Comprehensive biochemical and endocrine evaluation was performed using the peripheral blood samples.</p> Results <p>Only CRP and LDH were found to correlate to disease severity and clinically relevant. Severe patients from three subgroups (except COVID-19 with T2DM) had significantly increased levels of CRP, ALT, AST, DB and Mg, while levels of cholesterol, T3 and LDL were found to be lower. HbA1c levels were higher in severe patients of non-diabetic subgroups.</p> Conclusion <p>This study provides a detailed informative analysis which could be referred towards understanding the dynamics of infection-associated complications. COVID-19-associated immune aberrations along with existing comorbidities could differentially influence biochemical and endocrine profiles in both mild and severe patients with and without diabetes and/or obesity.</p> Highlights <p><UnorderedList Mark="Bullet"> <ItemContent> <p>This study comparatively evaluates 30 biochemical and endocrine parameters in COVID -19 patients.</p> </ItemContent> <ItemContent> <p>Diabetic/obese patients with CAD and/or CKD exhibited poor prognosis and highest mortality rate.</p> </ItemContent> <ItemContent> <p>Use of GC drugs negatively affects the HbA1c levels in severely affected non-diabetic subgroups.</p> </ItemContent> <ItemContent> <p>Only LDH and CRP were found to be clinically significant among all patients with and without stratification.</p> </ItemContent> </UnorderedList></p>

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Influence of COVID-19 on biochemical and endocrine profiles of patients with and without type 2 diabetes and/or obesity

  • 期刊论文

  • 发表日期：

    2025年1月7日

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  • Shivani Jaiswal,
  • Vandana Dhiman,
  • Rahul Tiwari,
  • Preetam Basak,
  • Naresh Sachdeva,
  • Ravi Shah,
  • Vivek Sharma,
  • Mini P. Singh,
  • Sant Ram,
  • Kathirvel S.,
  • Gaurav Sharma,
  • Sanjay Kumar Bhadada

摘要

Background

Common comorbidities like type 2 diabetes mellitus and obesity along with their manifestations are linked to COVID-19 severity. Understanding perturbation in biochemical and endocrine parameters in these patients could help us define treatment modalities/guidelines for managing long COVID.

Objective

We attempted to comprehensively analyse various such markers to find their plausible influence on severity/mortality.

Methods

A total of 120 COVID-19 patients (mild and severe) were enrolled comprising four subgroups: COVID-19 only, COVID-19 with T2DM, COVID-19 with obesity and COVID-19 with T2DM and Obesity. Comprehensive biochemical and endocrine evaluation was performed using the peripheral blood samples.

Results

Only CRP and LDH were found to correlate to disease severity and clinically relevant. Severe patients from three subgroups (except COVID-19 with T2DM) had significantly increased levels of CRP, ALT, AST, DB and Mg, while levels of cholesterol, T3 and LDL were found to be lower. HbA1c levels were higher in severe patients of non-diabetic subgroups.

Conclusion

This study provides a detailed informative analysis which could be referred towards understanding the dynamics of infection-associated complications. COVID-19-associated immune aberrations along with existing comorbidities could differentially influence biochemical and endocrine profiles in both mild and severe patients with and without diabetes and/or obesity.

Highlights

This study comparatively evaluates 30 biochemical and endocrine parameters in COVID -19 patients.

Diabetic/obese patients with CAD and/or CKD exhibited poor prognosis and highest mortality rate.

Use of GC drugs negatively affects the HbA1c levels in severely affected non-diabetic subgroups.

Only LDH and CRP were found to be clinically significant among all patients with and without stratification.