Predictive value of aberrant serum miR-1224 in diabetes mellitus with chronic heart failure patients

Heart failure (HF) is one of the most common complications of type 2 diabetes mellitus (T2DM). The significant morbidity and mortality associated with the combination of T2DM and HF have increasingly drawn clinical attention.

To investigate the expression of miR-1224 in T2DM patients with chronic heart failure (CHF). The diagnostic value of miR-1224 in T2DM patients with CHF was further evaluated.

A total of 95 T2DM patients and 95 T2DM patients with CHF were enrolled in this study. RT-qPCR was used to detect the expression level of miR-1224 in the serum of patients in the two groups. ROC curve was drawn to evaluate the diagnostic value of miR-1224 in the two groups of patients. Binary logistic regression was used to analyze the effect of miR-1224 and other factors on the rehospitalization rate of T2DM patients with CHF.

The serum miR-1224 expression level was significantly higher in T2DM patients with CHF than in those without CHF. As the NYHA classification increased, so did the expression level of miR-1224. The miR-1224 could diagnose T2DM combined with CHF and was a factor influencing rehospitalization in T2DM and CHF patients.

The study suggests a correlation between miR-1224 and cardiac function, as well as the diagnosis and rehospitalization rates of T2DM patients with CHF. It proposes that miR-1224 could serve as a new biomarker for diagnosing T2DM with CHF.