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<p>Peptide modification enhances the physicochemical properties of peptides by introducing specific chemical groups or structural adjustments, but achieving site-selective modification remains a significant challenge. Recently, the selective functionalization of peptides, particularly through metal catalysis, has attracted growing attention. Gold catalysts, in particular, have emerged as a powerful tool due to their high catalytic efficiency, exceptional stability, and biocompatibility. Gold-catalyzed peptide modifications can improve target specificity, modulate protein–protein interactions, and enable precise control over functional group incorporation. This review focuses on the latest advancements in gold-catalyzed site-selective functionalization of peptides, by providing a detailed overview of these developments, we aim to increase understanding in the field and encourage further exploration of gold-mediated peptide modifications.</p>

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Gold-catalyzed selective modification of peptides: synthesis of cyclic and acyclic peptide derivatives

  • 期刊论文

  • 发表日期：

    2025年3月20日

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  • Guozhi Zhao,
  • Chengjie Guo,
  • Dongping Wang,
  • Zhenhua Jia,
  • Teck-Peng Loh

摘要

Peptide modification enhances the physicochemical properties of peptides by introducing specific chemical groups or structural adjustments, but achieving site-selective modification remains a significant challenge. Recently, the selective functionalization of peptides, particularly through metal catalysis, has attracted growing attention. Gold catalysts, in particular, have emerged as a powerful tool due to their high catalytic efficiency, exceptional stability, and biocompatibility. Gold-catalyzed peptide modifications can improve target specificity, modulate protein–protein interactions, and enable precise control over functional group incorporation. This review focuses on the latest advancements in gold-catalyzed site-selective functionalization of peptides, by providing a detailed overview of these developments, we aim to increase understanding in the field and encourage further exploration of gold-mediated peptide modifications.