Scholarlink

<p>The versatile features and increasing demand for biologically synthesized zinc oxide nanoparticles (bio-ZnO-NPs) make them targeted materials for medical and industrial applications. In this study, bio-ZnO-NPs were synthesized by <i>Punica granatum</i> peel extract as a capping and reducing agent. UV-Vis spectroscopy showed a characteristic absorption peak at 375&#xa0;nm. With an average crystallite size of 50 ± 6&#xa0;nm, X-ray diffraction (XRD) analysis demonstrated a hexagonal crystallite structure. Scanning electron microscopy (SEM) images indicated uniform, hexagonal-shaped nanoparticles, while energy-dispersive X-ray spectroscopy (EDX) confirmed the elemental composition of ZnO. Fourier transform infrared (FTIR) spectroscopy identified functional groups associated with phenolic compounds from <i>P. granatum</i> peel, indicating their role in nanoparticle stabilization. Using the FP-LAPW (full potential-linearized plane wave) technique and Density Functional Theory (DFT), the electronic and optical characters of ZnO were computed. Female mice were orally administered with different doses (50, 150, 250&#xa0;mg/kg body weight) of bio-ZnO-NPs for 21 days. Histopathological examination revealed dose-dependent alterations in ovarian tissues, including changes in follicular structures and altered estrogen and progesterone levels in treated groups. Hematological parameters were also changed in a dose-dependent manner and reduced body weight was observed. The results indicate that bio-ZnO-NPs may have some positive impact but higher doses can induce histological and physiological changes in the female reproductive system. This study provides insights into the potential effects of bio-ZnO-NPs on reproductive health and highlights the need for further research on their safety and applications. Understanding the dose-dependent effect is essential for optimizing their use in the nanomedicine while minimizing potential health risk.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

ZnO nanoparticles synthesized from pomegranate peel extract: physicochemical characterization and reproductive toxicity study on female mice

  • 期刊论文

  • 发表日期：

    2026年7月25日

查看全文
  • Samreen Qasim,
  • Asia Iqbal,
  • Shagufta Irshad,
  • Kashif Ali,
  • Ejaz Ahmad Khera,
  • Monika Michalska,
  • Faisal Mukhtar,
  • Rahman Shah Zaib Saleem,
  • Anum Farhan,
  • Wan Izhan Nawawi Wan Ismail

摘要

The versatile features and increasing demand for biologically synthesized zinc oxide nanoparticles (bio-ZnO-NPs) make them targeted materials for medical and industrial applications. In this study, bio-ZnO-NPs were synthesized by Punica granatum peel extract as a capping and reducing agent. UV-Vis spectroscopy showed a characteristic absorption peak at 375 nm. With an average crystallite size of 50 ± 6 nm, X-ray diffraction (XRD) analysis demonstrated a hexagonal crystallite structure. Scanning electron microscopy (SEM) images indicated uniform, hexagonal-shaped nanoparticles, while energy-dispersive X-ray spectroscopy (EDX) confirmed the elemental composition of ZnO. Fourier transform infrared (FTIR) spectroscopy identified functional groups associated with phenolic compounds from P. granatum peel, indicating their role in nanoparticle stabilization. Using the FP-LAPW (full potential-linearized plane wave) technique and Density Functional Theory (DFT), the electronic and optical characters of ZnO were computed. Female mice were orally administered with different doses (50, 150, 250 mg/kg body weight) of bio-ZnO-NPs for 21 days. Histopathological examination revealed dose-dependent alterations in ovarian tissues, including changes in follicular structures and altered estrogen and progesterone levels in treated groups. Hematological parameters were also changed in a dose-dependent manner and reduced body weight was observed. The results indicate that bio-ZnO-NPs may have some positive impact but higher doses can induce histological and physiological changes in the female reproductive system. This study provides insights into the potential effects of bio-ZnO-NPs on reproductive health and highlights the need for further research on their safety and applications. Understanding the dose-dependent effect is essential for optimizing their use in the nanomedicine while minimizing potential health risk.

Graphical abstract