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<p>Agricultural waste management poses significant environmental challenges due to improper disposal of residues. Valorization of agro-waste for producing pharmaceutically important compounds through mushroom cultivation can be a good alternative. This study reports cultivation of <i>Pleurotus ostreatus</i> mushroom using Ramie decorticated residue and bamboo waste. The growth parameters and biological efficiency of the agro-wastes revealed faster onset of mycelium growth, completion of mycelium growth, and pinhead initiation on Ramie decorticated residue compared to bamboo waste. The biological efficiency of Ramie decorticated residue (97.9%) was significantly (p-value 0.014) higher than bamboo waste (64.6%). The mushrooms grown on Ramie decorticated residue and bamboo waste were found to contain crude fiber (10.3% and 9.64%), fat (1.6% and 4.81%), protein (17.28% and 16.98%), carbohydrate (60.69% and 51.69%), ash content (4.71 and 7.91%), and energy (326.28 and 317.97 Kcal/100gm) within the normal range respectively. The estimated daily intake, bioaccumulation factor, and hazard quotient analysis of the heavy metal content revealed that both substrates produced edible mushrooms. Liquid chromatography-mass spectrometric analysis revealed Ramie decorticated residue grown mushrooms to contain Ergosterol derivatives, Ergost-2,5,7,9(11),22-pentaene showing highest binding affinity with vascular endothelial growth factor, Ergost-7-en-3β-ol with DNA gyrase subunit β, while Ergost-5,7,9(11),22-tetraen-3β-o with α-sterol demethylase following insilico analysis through PyRx and AutoDock 4.2.6. Those grown on bamboo waste produced Ergost-2,5,7,9(11),22-pentaene showing strong binding with vascular endothelial growth factor. These mushrooms could serve as raw material for the extraction of pharmaceutically important Ergosterol derivatives, hence leading to the valorization of agro-waste into raw material for pharmaceutical applications.</p> Graphical Abstract <p></p>

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Valorization of lignocellulosic agro-wastes for cultivation of Pleurotus ostreatus: nutritional evaluation and LC–MS based metabolic profiling of ergosterol derivatives

  • 期刊论文

  • 发表日期：

    2026年4月21日

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  • Espita Palwan,
  • Abinash Debbarma,
  • Sadon Sing Molsom,
  • Diptanu Reang,
  • Arabinda Ghosh,
  • Pratap Chandra Acharya,
  • Shaon Ray Chaudhuri

摘要

Agricultural waste management poses significant environmental challenges due to improper disposal of residues. Valorization of agro-waste for producing pharmaceutically important compounds through mushroom cultivation can be a good alternative. This study reports cultivation of Pleurotus ostreatus mushroom using Ramie decorticated residue and bamboo waste. The growth parameters and biological efficiency of the agro-wastes revealed faster onset of mycelium growth, completion of mycelium growth, and pinhead initiation on Ramie decorticated residue compared to bamboo waste. The biological efficiency of Ramie decorticated residue (97.9%) was significantly (p-value 0.014) higher than bamboo waste (64.6%). The mushrooms grown on Ramie decorticated residue and bamboo waste were found to contain crude fiber (10.3% and 9.64%), fat (1.6% and 4.81%), protein (17.28% and 16.98%), carbohydrate (60.69% and 51.69%), ash content (4.71 and 7.91%), and energy (326.28 and 317.97 Kcal/100gm) within the normal range respectively. The estimated daily intake, bioaccumulation factor, and hazard quotient analysis of the heavy metal content revealed that both substrates produced edible mushrooms. Liquid chromatography-mass spectrometric analysis revealed Ramie decorticated residue grown mushrooms to contain Ergosterol derivatives, Ergost-2,5,7,9(11),22-pentaene showing highest binding affinity with vascular endothelial growth factor, Ergost-7-en-3β-ol with DNA gyrase subunit β, while Ergost-5,7,9(11),22-tetraen-3β-o with α-sterol demethylase following insilico analysis through PyRx and AutoDock 4.2.6. Those grown on bamboo waste produced Ergost-2,5,7,9(11),22-pentaene showing strong binding with vascular endothelial growth factor. These mushrooms could serve as raw material for the extraction of pharmaceutically important Ergosterol derivatives, hence leading to the valorization of agro-waste into raw material for pharmaceutical applications.

Graphical Abstract