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<p><i>Thuja</i> <i>orientalis</i>, known for its medicinal properties, necessitates an effective and environmentally friendly approach for extracting its bioactive natural compounds on a large scale. This research was focused on optimizing the microwave-assisted extraction (MAE) method of <i>Thuja orientalis</i> cones using response surface methodology (RSM) and 70% hydro-ethanol as the solvent. The study assessed various parameters such as total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity using DPPH and ABTS radical scavenging assays, as well as metal chelating activity (MCA). The models obtained were well-suited, and the optimized conditions were determined as follows: a solvent-to-solid ratio of 30&#xa0;mL/g, power of 580 W, and extraction time of 90&#xa0;s. This resulted in optimal TPC of 393.11&#xa0;mg gallic acid equivalent (GAE)/g dry weight (DW), TFC of 36.12&#xa0;mg rutin equivalent (RE)/g DW, DPPH-RSA of 58.23%, ABTS-RSA of 61.72%, and MCA of 67.32%. This research transforms plant waste into value by efficiently utilizing <i>T. orientalis</i> cones, demonstrating their potential for sustainable industrial applications through an eco-friendly, large-scale extraction approach for obtaining valuable phytoconstituents with therapeutic values.</p>

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Green extraction of bioactive compounds from Thuja orientalis cones using microwave-assisted extraction and optimization by response surface methodology

  • 期刊论文

  • 发表日期：

    2025年2月6日

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  • Rana Haris Abdullah,
  • Faiza Imtiaz,
  • Dildar Ahmed,
  • Samra Ihsan,
  • Arfaa Sajid,
  • Qaisar Manzoor,
  • Muhammad Idrees Jilani

摘要

Thuja orientalis, known for its medicinal properties, necessitates an effective and environmentally friendly approach for extracting its bioactive natural compounds on a large scale. This research was focused on optimizing the microwave-assisted extraction (MAE) method of Thuja orientalis cones using response surface methodology (RSM) and 70% hydro-ethanol as the solvent. The study assessed various parameters such as total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity using DPPH and ABTS radical scavenging assays, as well as metal chelating activity (MCA). The models obtained were well-suited, and the optimized conditions were determined as follows: a solvent-to-solid ratio of 30 mL/g, power of 580 W, and extraction time of 90 s. This resulted in optimal TPC of 393.11 mg gallic acid equivalent (GAE)/g dry weight (DW), TFC of 36.12 mg rutin equivalent (RE)/g DW, DPPH-RSA of 58.23%, ABTS-RSA of 61.72%, and MCA of 67.32%. This research transforms plant waste into value by efficiently utilizing T. orientalis cones, demonstrating their potential for sustainable industrial applications through an eco-friendly, large-scale extraction approach for obtaining valuable phytoconstituents with therapeutic values.